How Cannabidiol (CBD) Works for Treating Anxiety

How Cannabidiol (CBD) Works for Treating Anxiety

by Jeremy Kossen at www.leafly.com

While we don’t normally think of anxiety as desirable, it’s actually a critical adaptive response that can help us cope with threats to our (or a loved one’s) safety and welfare. These responses help us recognize and avert potential threats; they can also help motivate us to take action to better our situation (work harder, pay bills, improve relationships, etc.). However, when we don’t manage these natural responses effectively, they can become maladaptive and impact our work and relationships. This can lead to clinically diagnosable anxiety-related disorders. We’ve all heard the saying, “stress kills.” It’s true!

Anxiety-related disorders affect a huge segment of our population—40 million adults (18%) in the United States age 18 and older. In response, Big Pharma has developed numerous drugs to treat anxiety-related disorders, from selective serotonin reuptake inhibitors (SSRIs) like Prozac and Zoloft to tranquilizers (the most popular class being benzodiazepines such as Valium and Xanax).

While these drugs can be effective for many patients, some don’t respond favorably. Certain patients don’t see much improvement, or they can’t tolerate the side effects. Moreover, tranquilizers like Valium and Xanax can be highly addictive. Clearly, alternative treatments are warranted. Could cannabidiol (CBD), the most prominent non-intoxicating constituent in cannabis, provide a viable alternative for currently available anxiety medications? Quite possibly!

In recent years, CBD has generated a tremendous amount of interest among consumers, clinicians, and scientists. Why? Not only does evidence suggest CBD counteracts many of THC’s adverse effects, but numerous animal studies and accumulating evidence from human experimental, clinical, and epidemiological studies suggest CBD has powerful anti-anxiety properties. Administered acutely (“as needed”), it appears safe, well-tolerated, and may be beneficial to treat a number of anxiety-related disorders, including:

  • Panic disorder

  • Obsessive Compulsive Disorder (OCD)

  • Social phobia

  • Post-Traumatic Stress Disorder (PTSD)

  • Generalized Anxiety Disorder (GAD)

  • Mild to moderate depression

How Does CBD Work?

CBD exerts several actions in the brain that explain why it could be effective in treating anxiety. Before we dive in, it’s important to note that most research describing how CBD works is preclinical and based on animal studies. As the saying goes, “mice are not men” — and, results from animal studies don’t always neatly transfer to human therapies. However, preclinical studies provide insights that move us in the right direction:

5-HT1A agonist: 5-HT1A is a subtype of the serotonin receptor, which is important because anxiety and depression can sometimes be treated with medications that target the serotonin system. This is why drug companies developed selective serotonin reuptake inhibitors (SSRIs) like Prozac and Zoloft. SSRIs work by blocking reabsorption of serotonin in the brain, which increases availability of serotonin in the synaptic space. This helps brain cells transmit more serotonin signals, which can reduce anxiety and boost mood in certain cases (although the full biological basis for this is more complicated and not fully understood).

Similar to SSRIs, CBD may boost signaling through serotonin receptors. In an animal study, Spanish researchers found that CBD enhances 5-HT1A transmission and may affect serotonin faster than SSRIs. Researchers noted:

“The fast onset of antidepressant action of CBD and the simultaneous anxiolytic (anti-anxiety) effect would solve some of the main limitations of current antidepressant therapies.”

Hippocampal neurogenesis: The hippocampus is a major brain area, and plays a critical role in a variety of brain functions. It’s most famous for its role in memory formation and cognition. Brain scans of patients suffering from depression or anxiety often show a smaller hippocampus, and successful treatment of depression is associated with the birth of new neurons (neurogenesis) in the hippocampus.

An animal study using mice found repeated administration of CBD may help the hippocampus regenerate neurons, which could be useful for treating anxiety or depression. Research shows both SSRIs and CBD may promote neurogenesis. This is significant, because evidence suggests that severely impaired neuronal plasticity may influence suicidal behavior. Future research comparing CBD and SSRIs effect on neurogenesis could open up promising new avenues in how we understand depression and how to most effectively treat it.

How Can CBD Help Anxiety?

Building on the foundation of animal studies, human studies are starting to provide evidence to demonstrate that CBD can improve many commonly reported anxiety-disorder symptoms, including acute stress and anxiety.

Human Studies Show How CBD Reduces Anxiety

Brazilian researchers conducted a small double-blind study of patients afflicted with generalized social anxiety. After consuming CBD, participants reported a significant decrease in anxiety. Researchers validated patients’ subjective reports by performing brain scans showing cerebral blood flow patterns consistent with an anti-anxiety effect.

In another small study, researchers had patients suffering from Social Anxiety Disorder perform a simulated public speaking test. Participants reported significantly less anxiety, findings supported by objective anxiety indicators like heart rate and blood pressure.

Researchers concluded, “[CBD] significantly reduced anxiety, cognitive impairment, and discomfort in their speech performance,” whereas the placebo group experienced “higher anxiety, cognitive impairment, [and] discomfort.”

Final Thoughts

Evidence from animal studies have begun to characterize the details of how CBD acts in the brain, and human studies of patients with and without anxiety disorders are starting to validate CBD’s efficacy as an anti-anxiety treatment. Given the huge social and financial costs of anxiety disorders in the U.S., CBD has the potential to play a significant role in treating a myriad of anxiety-related disorders.

While more research, including large randomized-control trials (RCTs), is clearly warranted to examine the long-term effects and potential for CBD, its demonstrated efficacy and highly favorable safety profile (particularly when compared to currently available drugs) make it a viable alternative or adjunct to currently available pharmaceuticals.

References

Blessing EM, Steenkamp MM, Manzanares J, Marmar CR. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics. 2015;12(4):825-36. PDF

Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci. 2000;20(24):9104-10. PDF

Zlebnik NE, Cheer JF. Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation?. Annu Rev Neurosci. 2016;39:1-17. PDF

CBD illegal before it ws discovered???

This short article came from a larger article on ProjectCBD.org by Martin Lee, June 11, 2019

CBD became illegal before it was discovered.

Cannabis was effectively outlawed by the federal government in 1937 with the passage and implementation of the Marihuana Tax Act. The Act explicitly stated that cannabis resin or any extract from the resin was considered to be “marihuana” (i.e. the Evil Weed). Cannabidiol (CBD) is found in the resin, nowhere else in the plant. (Tetrahydrocannabinol – THC, aka The High Causer – is also concentrated in the resin along with a slew of other therapeutic compounds.) In effect, CBD, a nonintoxicating cannabis component, was prohibited by federal law before anyone actually knew that CBD existed.

It wasn’t until 1940 that Roger Adams, a University of Illinois chemist, first identified and synthesized CBD. Two years later, he was awarded a patent for his unique method of isolating CBD. Adams observed that CBD had pain-killing properties and he contributed to the 1944 La Guardia Report on the Marihuana Problem, which debunked many of the scaremongering reefer madness claims promoted by the Federal Bureau of Narcotics. By the time Adams retired in 1957, he had published 27 studies on CBD and other plant cannabinoids. He was subsequently honored by the American Chemical Society, which established the prestigious Roger Adams Award in recognition of his life’s work. Israeli scientist Raphael Mechoulam picked up where Adams left off and elucidated the precise molecular structure of CBD in 1963. And he did the same for THC in 1964.

Fallacies on Hemp and CBD.....

So, I was reading a recent article by ProjectCBD.org by By Martin A. Lee & Zoe Sigman On May 22, 2019 .

It is a great article on 5 fallacies of hemp, we are talking about the industrial hemp plant that is used to make fiber, construction material, etc… I think it is important to understand these myths because people blindly purchase products because the producer says it’s great…but in reality they are not as effective or tranparent by putting the important information on the labels of the products that clearly tell the consumer how much of each cannabinoid is in the product. There is ALOT of misinformation out there and people that I know think that CBD oil is all the same….WRONG!! They still don’t know the difference between hemp derived CBD oil and a tincture made from the whole plant of a cannabis strain which contains so much more CBD than hemp. Here is one of the myths Martin Lee from ProjectCBD talks about…..please read this short article and please share it with your friends and family so they can be educated on the subject!

Elizabeth

Fallicy #5 - Industrial hemp is a good source for extracting CBD oil.

The CBD molecule is exactly the same whether extracted from industrial hemp or other forms of cannabis. But the quality of the CBD products made from industrial hemp that’s grown for fiber or seed protein is typically inferior to the products made from CBD-rich “drug” plants that are grown specifically for medicinal oil extraction.

The quality of the CBD products made from industrial hemp is typically inferior to the products made from CBD-rich “drug” plants.

CBD is the most common cannabinoid present in industrial hemp, but the CBD levels top out at about 3.5% by dry weight – much less than the remarkable varieties of CBD-rich cannabs flower grown for medicine that can reach as high as 20% CBD by dry weight. Because industrial hemp produces relatively small amounts of CBD, a huge amount of hemp biomass is necessary to produce a significant quantity of CBD oil. (This equals more land and more waste!)

Such a large amount of plant material means there’s a greater likelihood that toxic contaminants will be concentrated in the CBD oil extracted from industrial hemp, which will suck up and absorb any pesticides or heavy metals present in the soil through a process known as “bioaccumulation.” This is excellent for cleaning up a toxic waste site, but not so good for medicinal oil extraction and production. Industrial hemp and its extracts usually aren’t subject to stringent (state-level) regulations governing pesticide and solvent residues, and these contaminants end up in CBD products manufactured by unscrupulous producers.

It’s noteworthy that the phrasing of the 2018 Farm Bill refers to “hemp” rather than “industrial hemp.” The decision to drop the word “industrial” from legislative parlance is a reflection of the primacy of CBD in the brave new world of legal hemp. Industrial hemp cultivated for fiber and seed isn’t CBD-rich. But new high-resin cannabis cultivars are becoming available that have been bred specifically to produce copious quantities of CBD with less than 0.3 percent THC, thereby satisfying the federal government’s absurd legal criteria for hemp.

I will post the other fallacies Martin Lee talks about in the following blogs….

Testimonials

I have never posted testimonials from my clients, and now is the time! Over the years I have had many people give me feedback on the cannabis tinctures, both CBD and THC and the results they have seen with their health challenges.

CONDITIONS/TESTIMONIALS

Seizures

I've now been using Super High CBD Pianta Tinta since two days after I saw you on 4 March. I started with 5 drops on 6 March and on 9 March after consulting with Dr. XXXX, increased it to 10 drops (once a day, a couple hours before bedtime). As of last night she had me increase it to 15 drops. I'm adding it to a small amount of water in a spoon and trying to keep it sublingually and not swallow for as long as possible. I have on average 4-6 seizures a month and been on many medications which only put me in a zoombie state...I have been taking the SUPER High CBD tincture now for 2 1/2 months and have had only 1 seizure, and that is probably because I was sick at the time I had the one!. The CBD relaxes me before bed and I can fall asleep faster and am more functional in the morning. I take 5 drops in the am and 5-6 drops before bed.....Vallejo, CA

My dog has had many seizures due to a brain injury….only had one seizure since taking the CBD tincture….Barbara, Sierra Foothills

Usually I have what I describe as visual distortions with tightness of the head - these are auras actually. I tend toward a couple of those a day; they last just a few seconds. It seems in the last week those have decreased (I do write them down when they happen, otherwise they'd be very easy to forget about since they're brief). So I think your tincture is definitely helping....Walnut Creek, CA

I would like to refill my order of Super High CBD Tincture. FYI: I did not find much difference between your CBD tincture and the Charlotte’s Web, except their price/shipping (!) and that they flavor theirs with chocolate. I prefer yours, by far and, I have not had a seizure since, that I am aware of. I also like what this CBD does for my mood…..San Francisco, CA

Thank you for asking about how my daughter is doing. The first week she was taking 3 drops 3 times a day. She became very sleepy an hour after her medication the first week. Now, she has adjusted and is taking 6 drops 3 times a day. No more sleepiness, no redness in her eyes. She has had no seizure activity and does seem more relaxed. I hope to continue to slowly increase as the doctor advised. She did amazing in her physical therapy today! Any pain she has had is much better, too. 

 I am very satisfied and hopeful. Thank you for your product….Vanessa K.

 

I wanted to tell you I've tapered off from 8 Keppra a day to just four, over the course of about 6 months. Still taking 6 Lyrica a day. I don't notice any increase in auras, and now that things have slowed down after the holidays I can go one or two days with no auras at all….Walnut Creek, CA

 

Prostate Cancer

Member taking 10 drops per day, feels good more energy, urine smells like cannabis?

Cancer

Hi, dropping a line to let you know how I am doing.   Cancer marker in blood went from 283 down to 61,  pet scan showed cancer in fluid around right lung was almost gone and what little bit that is there is dormant, nothing changed in abdomen,  holding steady.  I still feel good.  Still taking CBD, but about a week ago I stopped taking the RSO.  The RSO was making me feel bad, made around my eyes swell up. I now take the CBD morning and night.  Drinking the essiac tea 2 times a day.  I had been drinking the tea about a month before I had the test done. I am hoping the tea and all the other stuff I am doing is what is making me beat the odds.  Also would like to think all the advice you have given me is making me feel good and keeping my cancer at bay.  Can't thank you enough.   Don't have to go back to doctor for 2 months, unless I take a turn for the worst, which that isn't going to happen.     L.R.

I received the RSO oil at 8:30 this morning after a sleepless night. I ingested tiny amount and slept from 9:30 to 2:30

I haven't slept that soundly in years. Yes, my wife thought I was dead….Sacramento,CA

 

Had blood work on the 5th  of this month.  Glucose was 111 and cancer marker went from 132 down to 79.  Had per scan yesterday and it showed my cancer hasn't changed….Lucy R.

 I'm soooo thrilled. My lesion is gone.  The kind of scary part of the treatment is the RSO appeared to eat the skin away, but it's gone & no scarring. 🏼….Deborah

 Elizabeth, I wanted to give you a quick up date my Dad's father in-law that has stage 4 cancer, made it back to the Philippines last week and will stay there.

 I wanted to thank you for being a part of this process of helping him get home….Brian C.

 The week we was evacuated i didn’t get to take CBD, turmeric and the rest of my vitimans.  I have wondered for a long time if the CBD and turmeric was actually doing me any good, i don’t have to wonder any more.  One week without them proved i need them.    Lucy

 

 Anxiety

It’s better than benzodiazepines. I had to rely on Clonazepam for those times when I know stress was inevitable. The CBD works better than Clonazepam. I used it on two recent trips that promised much stress and the CBD worked brilliantly. Calmness in social situations And...btw, it's SO good for social anxiety!!! I use it before parties, conferences, etc., situations where I would get somewhat anxious. And, it has given me the "guts" to book a trip to China, Vietnam, Cambodia, Laos, Thailand and Malaysia in the fall!!...Richmond, CA 

I have had frequent panic attacks for a long time and since starting on the CBD and relaxing tea they have decreased dramatically…Pacifica, CA

here's a short, interesting (I hope) story of CBD's effects on my anxiety. 

Two nights ago I had to stand up and give a 1 minute synopsis of the book I was currently pleasure-reading, as an ice-breaker-thing, to a roomful of 60 medical doctors and Ph.Ds. This was at a medical conference at Lake Tahoe. Things like this usually terrify me. I'm not a medical doctor, not a public speaker, not particularly well-spoken; but while "on" CBD, I calmly gave the synopsis without fear. I think it went well. Not only was I not nervous or apprehensive when I knew my moment was approaching, but I did not analyze my little public-speaking event after it was over throughout the rest of the night in my head with negative self-talk!!!!

Thank you for the important work you are doing. R.F.

I can think clearer... less anxiety...( like no need for any Valium ) I'm able to laugh more ( not a stoned laugh at everything laugh) just an enjoy my grand babies laugh. 

I don't know if I can contribute this to it but it seems if I add a few drops at night my nightmares are less and my dreams are happier... ( I have PTSD that I'm working through which came with horrid violent nightmares)

It seems to give me an overall feeling of well being. With no high !

Thank you again for all the work you do! 

I feel like I'm getting my life back ! You're a Godsend!....Amanda F.

 

I am really liking the tinctures, I especially like combining the CBD and THC for the relaxing effect. It has been helping lower anxiety, insomnia and back pain. My stomach/intestinal issues are slowly getting better as well, which seem to be largely stress related so I think it is contributing to my overall healing….aaron

 

So just a quick update for you...K. is still on 6 drops twice daily and seems to overall be feeling even a little bit more less anxious than before. They report feeling overall "Happier" than before! Some days they still experience the generalized anxiety but overall I think its been very helpful. They made it through all of the excitement of the Fourth and through the Conference this past weekend with only a little fallout ( which for us is HUGE!! ) Normally they get overstimulated during big, exciting events like these and cant manage the sensory overload. So thank you very very much and I look forward to them hopefully making even more progress as time goes on…E.F.

 

  Shingles

Knocked the Shingles out in about a week. I was using about 15 drops at night at the time sometimes a bit during the day as well and sleeping a lot. I'm down to 5 drops a night to help with sleep and it is helping…Vallejo, CA

 I use the high CBD tincture in the morning and that knocks out the itch.  I have been trying the oil at night for sleeping.  It helps.  I have been a lifelong bad sleeper, but the oil helps.  I also like the 50/50 at night….Oakland, CA

I have had shingles for the past month and have gone through my supply from a few weeks ago.  The good news is that the tinctures have been extremely effective and I have not had to use any narcotic pain medications and have only taken ibuprofen twice.   I am now getting near the end of the illness but I certainly don't want to run out.  Between the 2 products I was able to get some sleep at night and adequately manage the level of pain during the day.  I am very thankful for them! ….Elizabeth B.

Glaucoma

High CBD reduced my ocular pressure behind eyes...from 26 to 22 in one eye and stayed at 26 in other eye. As of 4/16/15, the pressure is down to 16 and 17…..San Francisco, CA

Pain

I just wanted to thank you for sending me that article from Dr. Bonni Goldstein regarding nerve related pain. I can’t even begin to tell you how much it helped! I’ve dealt with nerve pain since 1996 and have been poked and prodded and experimented on by doctors in an attempt to be free of the pain and get a good night’s sleep.  I’m not able to take pain medication (nor did I want to) so my only form of relief was wearing a TENS unit. During the day it wasn’t so bad but at night it got tricky. The gel pads and wires only stay in place if I lay very, very still and apparently that’s impossible for me to do. I always woke up multiple times per night with gel pads stuck to my face, my hair, or my husband. Since I’ve started using the proper combination of CBD and THC tinctures and following Dr. Goldstein’s recommendations I am now able to sleep through the night without my TENS unit! I do quite a bit of traveling every month and was not able to endure sitting in a car or riding on a plane without that ever-present TENS unit. But now I don’t even need it!  In fact, I don’t even remember where it is! Is the pain completely gone? No. But it’s at such a manageable level because of the CBD/THC tincture that I feel like I am living a normal life for the first time in more than 20 years. Thank you so much! ….Marge M.

I would also like to report that the high CBD balm you recommended is also fantastic for achy joints (my knees in particular) and muscles (my lower back). It works almost immediately and there is no overt sensation other than the virtual cessation of discomfort in those areas. Alas, the effect is not too long-lasting (a couple of blissful hours) but such is the nature of aging - pain becomes ever more abundant as our youth recedes in the rear view mirror"... Jonathan

It has helped with my pain.  I have stayed with the 10 drops a day.  I mainly use it at the end of the day.  It relaxes me as well and I can fall asleep faster with it….,Vallejo, CA

Anti-inflammatory properties. As an old-ish guy, I push my body farther than I should, so I know all about joint inflammation, and this helps. I have lots of Vicodin, but take it sparingly, if at all. But the CBD provides pain-relief that is just as good as Vicodin for me…Richmond, CA

I have been using the CBD drops daily with great results for a couple months now. I have worked up to 15 drops twice a day, morning and afternoon. I take them sub-lingually with juice. If I’m in pain and think it will affect my sleep, I take 10-15 drops of the 50/50 blend before bedtime. (I've noticed taking these during the day has made me feel a little hazy/sleepy/lethargic, so I use these exclusively at night). My main reason for taking the CBD drops was for my back and sciatic pain. Second to this is my ADD and stress levels. My overall pain level has been reduced. The pain is still there but it feels lessened and dulled. I also feel a better sense of overall calmness, I feel like the internal mind chatter and constant thoughts are calmed a bit as well……Vallejo, CA

I have been on the drops for almost a week now. I am up to 8 drops 3x's a day. I am finding that I am less and less stiff - especially in the AM, and requiring less pain meds.....Walnut creek, CA

I just wanted to check in with you and let you know how I'm doing. I hope that you and yours have been well and enjoying this beautiful season!

So, last week I took 3 drops twice daily and noticed some very subtle changes. The first thing I noticed was feeling very clear headed, fresh and alert. What a joy! My pain levels were the same (6 to 7 on a pain scale) but by Saturday, my range of motion in turning my head became slightly better. I said, "hey this is new!" I'm starting to enjoy better sleep too: natural, deep, and healing!

This week I have used 4 drops twice daily. Today, my pain levels are lower and my range of motion is greater. I feel a strong pressure still but the sharp pains are gone from my neck, shoulders, and the base of skull. My arm and hand are especially heavy/strained though but  they have felt different ever since my nerve block. I know it's very early still and I will absolutely keep going with the tincture. Thank you also for your recommendations on taking it too. It's been a delicious experience finding just the right one,hehe!
I think I'm right around the corner from finding "my dose". I have a very strong positive feeling that this is going to be my "It". My neck hasn't felt this boring and uneventful (like a neck should feel,lol) in a VERY long time! I will be sure to keep you posted and will be sure to ask you any question that may arise along the way. This is becoming my favorite part of this healing journey~

Please accept my sincere gratitude for you and your partners who make this medicine available. You are truly life savers….Benicia

I am so impressed with the effects of the tinctures I am using. I have so much less pain than I did before. I feel good every day, without fatigue! I seriously have not felt this good in over a year and probabIy longer. I am continuing to regain range of motion in my left shoulder, the one with the rotator cuff problems. It's simply amazing. I am happy and relaxed in spite of the recent diagnosis of breast cancer!......Forest Ranch, CA

I've been able to maintain a little better in coping with his schizophrenic behavior, better quality of sleep with my fibromyalgia.  I do however, also take as needed, a product called sleep essentials or L-tryptophan at night along with the 50/50. But basically, the 50/50 helps get better quality, deeper sleep which is a big deal with fibromyalgia. I'm not where I need to be but definitely on my way….Vallejo, CA

BTW, I stopped my daytime dose for about 10 days and then went back on it and immediately my shoulder made another leap toward recovery. Such great medicine!! I've been hoeing weeds and cleaning up the yard and getting stronger. Yay!....Forest Ranch, CA

I'm so happy I found you b/c I tried a few other places and everything was just too strong, gave me anxiety, etc.  I feel yours is very pure and truly medicinal and I have also been giving it to my Mom and she is SO thankful   However, every other cartridge I have gotten from you has been perfect in the sense of feeling "medicinal" and a perfect amount. Not as much anxiety and my Mom is even off her pain meds!!!  This makes me and her SO happy.  So, we are grateful for you and your work.

Thanks again,  T.S.

 

One side effect I never expected was that my left heel would hurt so much it would wake me but now there's no pain during the night at all.  That's a huge hooray!    S.S….Walnut Creek, CA

 

I had spinal surgery two months ago and have utilized the pain medication I ordered several months ago and it really helped, and a great alternative to the opioid based meds prescribed by the surgeon.  Many thank, Sam

 

PMR

I have been on the drops for almost a week now. I am up to 8 drops 3x's a day. I am finding that I am less and less stiff - especially in the AM, and requiring less pain meds….Walnut Creek, CA

Neurofibromatosis

Just wanted to let you know that things are going well for my daughter with the CBD tincture.  It seems to be helping.  She is sleeping better and her pain is getting better.  We are trying to wean her off of Lyrica (neuropathic pain drug), which would be a great thing….San Diego, CA

Muscle Spasms

"I just wanted to follow up with you as it has been almost three weeks since I visited you in Vallejo. As you may recall during our consultation, you mentioned that CBD was particularly effective in treating muscle spasms of various kinds and I was prompted to tell you about the clicking in my ear that I came to know was caused by muscle spasms in the inner ear. After using the high CBD tinctures that you recommended for 3-4 days I found that the clicking in my ear had completely dissipated! Furthermore, I recently took a break from using the tinctures and, sure enough, after a couple of days the clicking is starting up again. In fact it was the clicking that made me think to send you this followup email.  ;-)…Jonathan

The pain rub calmed the spasms in my coccyx area and I have no need for narcotics with that particular rub. I am using the RSO THC oil tid (3) times@ day cause my muscles and nerves were starting to continually have spasms. The RSO oil is the most effective medicine that I’ve tried. I sleep well my spasms settle down, it AWESOME!!!.....Lucerne, CA

Brain Fog

I can tell that the CBD is making a difference. It's very good at clearing away my morning brain fog. I'm using 15 drops in the morning after walking the dogs and before eating breakfast. I noticed that I have been getting to sleep later than normal and waking up earlier than normal. I added a 10 drop booster in the mid-morning which seemed to help.....Walnut Creek, CA

Parkinson ’s disease

The jury's still out re: beneficial effect. Tentative observation: my super-small illegible handwriting (micrographia, common in Parkinson's) seems to have improved. No improvement in other symptoms, including unwanted involuntary movements (dyskinesia)……Chico, CA

Chrons/Colitis

The tincture does appear to be helping with both my Crohn's and migraines. I think for me the two are connected so it is not surprising it is helping for both. Primarily, I notice that my bowel movements are better when I'm taking it. The migraine stuff is hard to track and I figured out recently that I grind my teeth at night and a mouth guard has been helping with the migraines so it is hard for me to isolate cause and effect but I will keep doing experiments and let you know…..San Francisco, CA

I am really liking the tinctures, I especially like combining the CBD and THC for the relaxing effect. It has been helping lower anxiety, insomnia and back pain. My stomach/intestinal issues are slowly getting better as well, which seem to be largely stress related so I think it is contributing to my overall healing….Aaron from Vallejo

Psoriasis/Skin Conditions

 In general I would say that the psoriasis is backing off everywhere, which is great.  Hard to know exactly what it is I’m doing differently that is contributing to the positive change, I suspect some of all of what I’m doing is making this go in a better direction.  Certainly diet has been a big factor, since my auto-immune issues (Crohn’s & psoriasis) are gut related.  But I feel that your tinctures are also part of the remedy.  I’ve used both the 50/50 and Super high CBD topically, mixing them in warmed oil (at different times hemp, argan, coconut) and applying them topically to my scalp.  I’ve probably done some version of this treatment 4 times since my initial purchase of the tinctures.

I’ve taken the tinctures orally two to four times a week since the initial purchase.  I’ve switched between the two tinctures without noticing a different reaction from one or the other. The dose is around 5 to 7 drops per dose in a small glass of water, usually in the evening, and usually just one dose per day…..San Francisco, CA

 

Just wanted to say that my skin is looking really good. I'm also taking a lot of things away that perhaps also caused the inflammation but I'm pleasantly surprised at the change. And I feel great, too. So, thank you. Check out this before and after picture! Along with the cbd I also have totally eliminated alcohol and anything else that seemed to be causing more inflammation. Can't believe these results! Walnut Creek, CA

 

 

 

Arachnoiditis

The pain rub calmed the spasms in my coccyx area and I have no need for narcotics with that particular rub. I am using the RSO THC oil tid (3) times@ day because my muscles and nerves were starting to continually have spasms. The RSO oil is the most effective medicine that I’ve tried. I sleep well my spasms settle down, it is AWESOME!!! I am now off of all prescription paid meds.....Lucerne, CA

SLEEP

I'm mainly using it at night just before bed. I sleep as well as I did before menopause.  Consistently too. Good stuff…..Forest Ranch, CA

Thx, Elizabeth.  Yes, I really feel a difference with the cbd.  The thc is also really helping my sleep.  I tried a couple other companies, but theirs didn't seem as clean?....Mill Valley, CA

At this point I'm using 17 drops of the CBD and 7 drops of the THC for sleep and getting about 5-6 hours of sleep a night which is so much better than the 2-4 I used to get.  It's given me so much more energy and blood pressure has improved as well as has the a-fib (noticeable).  This has changed the direction of my life so I thank you. S

As I mentioned to you before, CBD was a lifesaver for me. But when I combined it with THC the positive effects on my insomnia and pain relief were remarkable! As you know, I personally don't want the psycho-activity of THC, but when combined with CBD, the synergy is remarkable. I don't experience psycho-activity, just a peaceful, relaxed feeling. For me, this is not a day-time formula. I've tried both components separately. Indica THC (Granddaddy Purple tincture) was good for sleep, CBD (AC/DC tincture) was spectacular for daytime/evening anxiety-relief. But for me, used together, I get everything I need to have a normal, relaxing evening and I ease into sleep very well. I still use CBD alone for daytime use.

I am really liking the tinctures, I especially like combining the CBD and THC for the relaxing effect. It has been helping lower anxiety, insomnia and back pain. My stomach/intestinal issues are slowly getting better as well, which seem to be largely stress related so I think it is contributing to my overall healing….Aaron from Vallejo

 

Thanks for all you do for so many of us. Keep up the good work….Robert

Blood Pressure

The really positive on this is my blood pressure has dropped like a stone and my heart palpitations (a-fib) have just about stopped!  The cardiologist felt I would more than likely need a pacemaker pretty soon but now I believe this has pushed that off so I'm thrilled.  S.S….Walnut Creek CA

 

Fibromyalgia

Yes the fibromyalgia is the biggest issue I'm trying to treat. 

I have found the high CBD has helped with muscle pain and joint pain and stiffness. I use the THC at night because I hadn't slept through the night in years. 

I can go to sleep and am getting more hours in a row than before. It's taken some time to turn that around but it's really helped. It too helps with the pain. 

I really hope she at least tries it. I think I've tried pretty much every other med and this has helped me more than everything else I've tried. 

 

Migranes

My daughter has far less migraines and rarely has to take her medication anymore!....A.F.

 

I am happy to report that I had a migraine the past two evenings and your tincture helped me enough that I didn't have to take my migraine meds.  It also helped me fall asleep even while I was still in pain.  Both days I woke up completely migraine free and without the nasty hangover my migraine meds give me.  I am very hopeful.  Thank you so much!....Heather N.

 

Psychosis/Gender non-binary

I have all positive updates for you!

 XXX is doing extremely well! They feel strong, happy, more confident and able to communicate better. XXX recovers faster from breakthrough episodes and overall remains calmer and more in control during them. Their medical team has noticed a significant positive change in them since starting the CBD! We are starting to cut back on some of XXX other medications and will hopefully eliminate many of them all together very soon. 

 

They have chosen to take 2 classes on the high school campus and even like having lunch in the cafeteria where they see their peers! 

 

We are starting SOAR next week (a 2 year outpatient program for kids with psychosis). We have also decided to apply for a psychiatric service dog to help provide XXX with even more independence, comfort and confidence. We haven't heard back yet if we've been accepted so fingers crossed. 

 

This is my first time reordering medicine from you so please let me know what to do. 

I cannot thank you enough for what you have done for my family….E.F.

 

XXX is currently very stable and upbeat. Their symptoms are low again. They're sleeping well, active, goal orientated, back in school part time, happy, and are able to process through many of lifes challenges successfully.

The SOAR program is going well. They are so helpful! We're  really still just getting started though.XXX had a set back in the beginning of Oct. Their symptoms increased and became dangerous. They started following the voice commands. I couldn't manage it safely at home so they had to check into a facility to stabilze and readjust medications. We had to stop the CBD while in the hospital because the staff wasnt willing to give it. But as soon as XXX was back home we restarted it, with Dr.XXX blessing again btw,lol, because he has witnessed what a huge impact its had on XXX. 

Thank you for caring about XXX and being a part of their healing journey. ….E.F.

 

 

 

 

 

 

 

Introducing CD-1 Candida

Why is it called "Candida"? It was named after the founder of Medical Marijuana Genetics late mother and means "Bright Light" in latin. It is a cross between two dynamic high CBD strains, AC/DC and Harlequin.

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It has one of the highest CBD and lowest THC contents of any strains available. CBD levels are between 10.9% and 20.6% and THC levels never passing 1%! Fantastic news for people that do not want the uncomfortable effects of too much THC. The anti-psychotic capabilities of the higher levels of CBD outweigh the relatively small amounts of THC therefore making it non-psychoactive.

The medicinal benefits of this strain go on and on... It’s high CBD concentrations make it ideal for helping a wide variety of conditions ranging from epilepsy, pain, inflammation, PTSD, anxiety/depression, ADHD, autism, neurodegeneration, MS, glaucoma, fibromyalgia, cancer, arthritis and much more. It can be used for daytime or nighttime. It can also be suitable for dogs/cats.

The most consistent dosing can be achieved by using a tincture. Our whole plant tinctures are third party lab tested and therapeutic strength with between 500-600 mg CBD per 1 oz bottle.

Email us with any question you might have! 

Elizabeth @ Pianta Tinta

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What is CBD?? A Short Video to Enlighten!

New to Medical Cannabis? You're not sure what CBD is?  If you have anyone you know that would like this education, please feel free to pass it on!!  Here is a short video on CBD, which stands for Cannabidiol, one of the many medicinal components of the cannabis plant and a major cannabinoid. Dr. Bonni Goldstein, Weedmaps and SC Labs put this together...good info!

THC and CBD for Medical and Recreational Users: What Are the Differences?

Whether you are a recreational or a medicinal cannabis user, you must have asked yourself this question at least once: what’s the difference between THC or CBD and which ratio should I go for when buying marijuana?

Both of these substances have their own benefits on our body and mind, always complementing each other.

Tetrahydrocannabinol (THC) and Cannabidiol (CBD) are cannabinoids, the two most prevalent chemicals in marijuana and the ones responsible for its popularity. There are more than 100 cannabinoids found in our favorite herb, but these two have been studied the most for their medical benefits.

These chemicals have a very positive impact on the human body — a group of cellular receptors and transmitters forms our very own cannabinoid system, which is in turn responsible for regulating hundreds of different bodily processes, including pain regulation, appetite, mood and many more.

Today we’re checking out an infographic from Greencamp which provides all the information about these two cannabinoids you will ever need, as well as a quick THC:CBD ratio guide that you can use to make better smoking decisions. So, let’s take a look at all the differences between these two mind blowing cannabis chemicals.

CBD Misconceptions

It doesn’t get you high, but it’s causing quite a buzz among medical scientists and patients. The past year has seen a surge of interest in cannabidiol (CBD), a non-intoxicating cannabis compound with significant therapeutic properties. Numerous commercial start-ups and internet retailers have jumped on the CBD bandwagon, touting CBD derived from industrial hemp as the next big thing, a miracle oil that can shrink tumors, quell seizures, and ease chronic pain—without making people feel “stoned.” But along with a growing awareness of cannabidiol as a potential health aid there has been a proliferation of misconceptions about CBD.

Read More

Benefits of both CBD and THC

So far the most studied cannabinoids from the cannabis plant are CBD(cannabidiol) and THC(delta-9-tetrahydrocannabinol) What are phytocannabinoids? They are the group of chemical compounds that are specifically found in the cannabis plant. There are over 400 chemical compounds in this special plant and when you are using cannabis you are getting a mixture of all of these natural compounds that work together to balance each other. I wanted to list the benefits of both CBD and THC to give you an idea of the main effects they have on the body. The following lists are from Dr. Bonni Goldstein's new book, Cannabis Revealed, a book I would highly recommend reading as it has science, how to use cannabis, dosing and patient stories...a well rounded book!

CBD EFFECTS

  • NOT psychoactive - no "high" effects
  • Alerting in low doses
  • Reduces pain
  • Relaxes muscle spasms
  • Potent anti-inflammatory
  • Stops nausea/vomiting
  • Reduces anxiety & depression
  • Counters psychotic thoughts
  • Anti-oxidant
  • Anti-convulsant
  • Neuro-protectant
  • Anti-tumor effects

THC EFFECTS

  • Psychoactive
  • Sedating/relaxing
  • Reduces pain
  • Reduces/stops nausea/vomiting
  • Stimulates appetite
  • Induces sleep
  • Reduces anxiety & depression
  • Reduces intraocular eye pressure
  • Anti-oxidant
  • Neuro-protectant
  • Anti-tumor effects

When CBD and THC are used independent of each other, many people of have found relief from a variety of ailments, but when they are used together, it is called "The Entourage Effect", meaning that the cannabinoids work better together than isolated from one another...an example that Dr. Goldstein gives in her book is both THC and CBD when taken separately, have pain relieving properties but there are studies that show CBD enhances pain relief when used together with THC, compared to using THC by itself.

I have had a few members that have been a bit frustrated when they didn't get the relief they wanted from chronic pain issues, but after they added a small amount of THC, the results were much better! If you keep the CBD dose higher than the THC many people do not get the "high" or psychoactive effects but still get the medicinal effects. Finding the right dose and the right combination for you does take a little time, so have fun and experiment with it!

 

Source: https://www.amazon.com/Cannabis-Revealed-m...

How does Cannabidiol (CBD) Work???

This article was originally published in O'Shaughnessy's Reader and reposted on the ProjectCBD website. Although some of it went over my head....I did get some interesting info from it. So give it a read and take what you can!!

Elizabeth - Pianta Tinta

Cannbidiol (CBD), a non-psychoactive component of the marijuana plant, has generated significant interest among scientists and physicians in recent years—but how CBD exerts its therapeutic impact on a molecular level is still being sorted out. Cannabidiol is a pleiotropic drug in that it produces many effects through multiple molecular pathways. CBD acts through various receptor-independent channels and by binding with a number of non-cannabinoid receptors and ion channels.

Here are some of the ways that CBD confers its therapeutic effects.

CBD and FAAH

Unlike psychoactive THC, CBD has little binding affinity to either the CB1 or CB2 cannabinoid receptors. Instead, CBD indirectly stimulates endogenous cannabinoid signaling by suppressing the enzyme fatty acid amide hydroxylase (FAAH)—the enzyme that breaks down anandamide, the first endocannabinoid discovered in the mammalian brain in 1992.

Whereas the cannabinoid molecules found in cannabis are considered “exogenous ligands” to the cannabinoid (CB) receptor family, anandamide is an “endogenous” cannabinoid ligand—meaning it binds to one or more cannabinoid receptors and is found naturally inside the mammalian brain and body. Anandamide favors the CB1 receptor, which is concentrated in the brain and central nervous system. Because FAAH is involved in the metabolic breakdown of anandamide, less FAAH means more anandamide remains present in the body for a longer duration. More anandamide means greater CB1 activation.

CBD enhances endocannabinoid tone by supressing FAAH.

By inhibiting the enzyme that metabolizes and degrades anandamide, CBD enhances the body’s innate protective endocannabinoid response. At the same time, CBD opposes the action of THC at the CB1 receptor, thereby muting the psychoactive effects of THC.

CBD also stimulates the release of 2-AG, another endocannabinoid that activates both CB1 and CB2 receptor. CB2 receptors are predominant in the peripheral nervous system and the immune system.

The Vanilloid Receptor

While CBD has little binding affinity for either of the two cannabinoid receptors, it has been shown to directly interact with other “G-protein-coupled” receptors and ion channels to confer a therapeutic effect. CBD, for example, binds to the TRPV-1 receptor, which is known to mediate pain perception, inflammation and body temperature.

TRPV is the technical abbreviation for “transient receptor potential cation channel subfamily V.” There are several dozen TRP receptor variants or subfamilies that mediate the effects of a wide range of medicinal herbs. 

Scientists also refer to TRPV-1 as the “vanilloid receptor,” named after the flavorful vanilla bean. Vanilla contains eugenol, an essential oil that has antiseptic and analgesic properties; it also helps to unclog blood vessels. Historically, the vanilla bean has been used as a folk cure for headaches.

CBD is a TRPV-1 “agonist” or stimulant. This is likely one of the reasons why CBD-rich cannabis is an effective treatment for neuropathic pain.

Capsaicin—the pungent compound in hot chili peppers—activates the TRVP-1 receptor. Anandamide, the endogenous cannabinoid, is also a TRPV-1 agonist.

The Serotonin Receptor

Jose Alexandre Crippa and his colleagues at the University of San Paulo in Brazil and at the King’s College in London have conducted pioneering research into CBD and the neural correlates of anxiety.

At high concentrations, CBD directly activates the 5-HT1A (hydroxytryptamine) serotonin receptor, thereby conferring an anti-depressant effect. This receptor is implicated in a range of biological and neurological processes, including (but not limited to) anxiety, addiction, appetite, sleep, pain perception, nausea and vomiting.

5-HT1A is a member of the family of 5-HT receptors, which are activated by the neurotransmitter serotonin. Found in both the central and peripheral nervous systems, 5-HT receptors trigger various intracellular cascades of chemical messages to produce either an excitatory or inhibitory response, depending on the chemical context of the message.

CBD triggers an inhibitory response that slows down 5-HT1A signaling. In comparison, LSD, mescaline, magic mushrooms, and several other hallucinogenic drugs activate a different type of 5-HT receptor that produces an excitatory response.

The Adenosine Receptor

CBD’s anxiolytic (anti-anxiety) properties may in part be attributable to its activation of the adenosine receptor. Adenosine receptors play significant roles in cardiovascular function, regulating myocardial oxygen consumption and coronary blood flow. The adenosine (A2A) receptor has broad anti-inflammatory effects throughout the body.

Adenosine receptors also play a significant role in the brain. They down-regulate the release of other neurotransmitters such as dopamine and glutamate.

GPR55

Whereas cannabidiol activates the TRPV-1 vanilloid receptor, the A2A adenosine receptor, and the 5-HT1A serotonin receptor, some studies indicate that CBD functions as an antagonist that blocks, or deactivates, another G protein-coupled receptor known as GPR55.

GPR55 has been dubbed an “orphan receptor” because scientists are still not sure if it belongs to a larger family of receptors.

GPR55 is widely expressed in the brain, especially in the cerebellum. It is involved in modulating blood pressure and bone density, among other physiological processes.

GPR55 promotes osteoclast cell function, which facilitates bone reabsorption. Overactive GPR55 receptor signaling is associated with osteoporosis.

GPR55, when activated, also promotes cancer cell proliferation, according to 2010 study by researchers at the Chinese Academy of Sciences in Shanghai. This receptor is expressed in various types of cancer.

CBD is a GPR55 antagonist, as University of Aberdeen scientist Ruth Ross disclosed at the 2010 conference of the International Cannabinoid Research Society in Lund, Sweden.

By blocking GPR55 signaling, CBD may act to decrease both bone reabsorption and cancer cell proliferation.

PPARs

CBD also exerts an anti-cancer effect by activating PPARs [peroxisome proliferator activated receptors] that are situated on the surface of the cell's nucleus. Activation of the receptor known as PPAR-gamma has an anti-proliferative effect as well as an ability to induce tumor regression in human lung cancer cell lines.

PPAR-gamma activation degrades amyloid-beta plaque, a key molecule linked to the development of Alzheimer’s disease. This is one of the reasons why cannabidiol, a PPAR-gamma agonist, may be a useful remedy for Alzheimer’s patients.

PPAR receptors also regulate genes that are involved in energy homeostasis, lipid uptake, insulin sensitivity, and other metabolic functions. Diabetics, accordingly, may benefit from a CBD-rich treatment regimen.

CBD’s enzyme-mediated activation of the PPAR-alpha receptor may have antipsychotic effects. Polymorphisms or mutations in the gene encoding PPAR-alpha can result in deficient PPAR-alpha signaling, which has been linked to schizophrenia. PPAR-alpha activation is both anti-inflammatory and can decrease dopamine release, thereby minimizing schizophrenic symptoms.