Whole plant CBD extract vs. synthetic single molecule

Back in February of this year a excellent Israeli study was done documenting the superior therapeutic properties of whole plant CBD-rich Cannabis extract as compared to synthetic, single-molecule cannabidiol (CBD) which is made in the lab. The notion that botanical extracts are "low grade and crude" as opposed to pure single molecule synthetic compounds made by the pharmaceutical companies is what was challenged. The study was Published in the journal Pharmacology & Pharmacy (Feb. 2015).

The study showed that administration of pure, single-molecule CBD resulted in a bell-shaped dose-response curve, that means when the amount of CBD exceeded a certain point its therapeutic impact declined dramatically. “Healing was only observed when CBD was given within a very limited dose range, whereas no beneficial effect was achieved at either lower or higher doses,” the authors observed. This characteristic of single-molecule CBD—manifested as a bell-shaped dose response—imposes serious obstacles that limit its usefulness in a clinical context.

The Israeli team sought to determine whether the administration of a whole plant CBD-rich extract would also generate a bell-shaped dose-response curve when administered to mice. Or would cannabidiol extracted from CBD-rich Cannabis avoid this liability? But a different dose response pattern was observed when the whole plant extract was administered to mice. Rather than showing a bell-shaped curve, where a therapeutic effect could only be achieved at a certain concentration of pure CBD, the whole plant CBD-rich extract caused a direct, dose-dependent inhibition of pain, inflammation, and TNFa production.

Moreover, the Israeli researchers found that a small amount of CBD in the whole plant extract was needed for significant pain relief compared to the much larger amount of pure single molecule CBD required to achieve the same analgesic effect. And whereas pure, single-molecule CBD precipitated a dramatic drop in efficacy if more than a specific dosage was administered, an “overdose” of whole plant CBD-rich extract did not undermine its therapeutic potency.

The body recognizes and can utilize substances that are natural, from nature. That is how we are made.  Anything that is synthetic is hard for the body to know what to do with it, yes, it can have an effect but in my opinion not as great an effect. The whole plant has not only cannabinoids, but terpenes and flavinoids and many other compounds which all work together synergistically and have positive effects in the body.

We here at Pianta Tinta are proud of our High CBD tincture in that we use the whole plant to extract out as much cannabinoids and other compounds to make the best medicine we can!

The above is just a small portion of the study done, if you wish to read the actual study click here.

A thank you to projectcbd.org for originally posting the article!

Elizabeth Knight, Pianta Tinta

 

Medical Studies show Cannabis cures Cancer

I recently was emailed the latest article on 420 Insight's website. I wanted to pass it along because it specifically deals with Cannabis and Cancer. The article was written by Arjun Walia and what I like about it is that it lists all the links to the studies for the different cancers.

This is an important article because one of the difficult obstacles someone with cancer deals with are FAMILY MEMBERS. Family members who will probably disagree with the way one goes about treatment, especially if it is non mainstream! With this information below one can give this information to the family members that are having a fit so that they are better educated about cannabis and how it affects cancer cells. Read and decide for yourselves! Thank you to 420 insight for the great articles and videos!  Elizabeth Knight

By Arjun Walia

The health benefits of Cannabis are vast, with multiple medical and scientific studies that confirm them. On the other hand, arguments against the use of marijuana is usually published in Psychiatric journals, which show no scientific evidence that Cannabis is harmful to human health. All psychological evaluations from the intake of cannabis are largely based on assumptions, suggestions and observations (1). When we look at the actual science behind Cannabis, the health benefits can be overwhelming. So what does one who opposes the use of cannabis base their belief on? Nothing, not scientific evidence anyways. The negative stigmatism attached to marijuana is due to it’s supposed psychotropic effects, yet again, there is no scientific evidence to show that marijuana has any psychotropic effects. Nonetheless, cannabis has recently been the focus of medical research and considered as a potential therapeutic treatment and cure for cancer.

Cannabis is a great example of how the human mind is programmed and conditioned to believe something. Growing up, we are told drugs are bad, which is very true, however not all substances that have been labelled as “drugs” by the government are harmful. Multiple substances are labelled as a “drug” in order to protect corporate interests. One example is the automobile and energy industry, a car made from hemp is stronger than steel, and can be fueled from hemp alone. Henry Ford demonstrated this many years ago. Hemp actually has over 50,000 uses!

Let’s take a look at the science behind Cannabis and Cancer. Although Cannabis has been proven to be effective for a large range of ailments, this article will focus mainly on it’s effectiveness in the treatment of cancer. Cannabinoids may very well be one of the best disease and cancer fighting treatments out there. Cannabinoids refer to any of a group of related compounds that include cannabinol and the active constituents of cannabis. They activate cannabinoid receptors in the body. The body itself produces compounds called endocannabinoids and they play a role in many processes within the body that help to create a healthy environment. Cannabinoids also play a role in immune system generation and re-generation. The body regenerates best when it’s saturated with Phyto-Cannabinoids. Cannabinoids can also be found in Cannabis. It is important to note that the cannabinoids are plentiful in both hemp and cannabis. One of the main differentiations between hemp and cannabis is simply that hemp only contains 0.3% THC while cannabis is 0.4% THC or higher. (Technically they are both strains of Cannabis Sativa.) Cannabinoids have been proven to reduce cancer cells as they have a great impact on the rebuilding of the immune system. While not every strain of cannabis has the same effect, more and more patients are seeing success in cancer reduction in a short period of time by using cannabis.

While taking a look at these studies, keep in mind that cannabis can be much more effective for medicinal purposes when we eat it rather than smoking it. Below are 20 medical studies that prove cannabis can be an effective treatment and possible cure for cancer. Please keep in mind that this is a very short list of studies that support the use of medicinal marijuana. Please feel free to further your research, hopefully this is a good starting point.

Brain Cancer

1 – A study published in the British Journal of Cancer, conducted by the Department of Biochemistry and Molecular Biology at Complutense University in Madrid, this study determined that Tetrahydrocannabinol (THC) and other cannabinoids inhibit tumour growth. They were responsible for the first clinical study aimed at assessing cannabinoid antitumoral action. Cannabinoid delivery was safe and was achieved with zero psychoactive effects. THC was found to decrease tumour cells in two out of the nine patients.

2 – A study published in The Journal of Neuroscience examined the biochemical events in both acute neuronal damage and in slowly progressive, neurodegenerative diseases. They conducted a magnetic resonance imaging study that looked at THC (the main active compound in marijuana) and found that it reduced neuronal injury in rats. The results of this study provide evidence that the cannabinoid system can serve to protect the brain against neurodegeneration.

3 – A study published in The Journal of Pharmacology And Experimental Therapeutics already acknowledged the fact that cannabinoids have been shown to possess antitumor properties. This study examined the effect of cannabidiol (CBD, non psychoactive cannabinoid compound) on human glioma cell lines. The addition of cannabidiol led to a dramatic drop in the viability of glioma cells. Glioma is the word used to describe brain tumour. The study concluded that cannabidiol was able to produce a significant antitumor activity.

4 – A study published in the journal Molecular Cancer Therapeutics outlines how brain tumours are highly resistant to current anticancer treatments, which makes it crucial to find new therapeutic strategies aimed at improving the poor prognosis of patients suffering from this disease. This study also demonstrated the reversal of tumour activity in Glioblastoma multiforme.

Breast Cancer

5 – A study published in the US National Library of Medicine, conducted by the California Pacific Medical Centre determined that cannabidiol (CBD) inhibits human breast cancer cell proliferation and invasion. They also demonstrated that CBD significantly reduces tumour mass.

6 – A study published in The Journal of Pharmacology and Experimental Therapeutics determined that THC as well as cannabidiol dramatically reduced breast cancer cell growth. They confirmed the potency and effectiveness of these compounds.

7 – A study published in the Journal Molecular Cancer showed that THC reduced tumour growth and tumour numbers. They determined that cannabinoids inhibit cancer cell proliferation, induce cancer cell apoptosis and impair tumour angiogenesis (all good things). This study provides strong evidence for the use of cannabinoid based therapies for the management of breast cancer.

8 – A study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) determined that cannabinoids inhibit human breast cancer cell proliferation.

Lung Cancer

9 – A study published in the journal Oncogene, by Harvard Medical Schools Experimental Medicine Department determined that THC inhibits epithelial growth factor induced lung cancer cell migration and more. They go on to state that THC should be explored as novel therapeutic molecules in controlling the growth and metastasis of certain lung cancers.

10 – A study published by the US National Library of Medicine by the Institute of Toxicology and Pharmacology, from the Department of General Surgery in Germany determined that cannabinoids inhibit cancer cell invasion. Effects were confirmed in primary tumour cells from a lung cancer patient. Overall, data indicated that cannabinoids decrease cancer cell invasiveness.

11 – A study published by the US National Library of Medicine, conducted by Harvard Medical School investigated the role of cannabinoid receptors in lung cancer cells. They determined its effectiveness and suggested that it should be used for treatment against lung cancer cells.

Prostate Cancer

12 – A study published in the US National Library of Medicine illustrates a decrease in prostatic cancer cells by acting through cannabinoid receptors.

13 – A study published in the US National Library of Medicine outlined multiple studies proving the effectiveness of cannabis on prostate cancer.

14. Another study published by the US National Library of Medicine determined that clinical testing of CBD against prostate carcinoma is a must. That cannabinoid receptor activation induces prostate carcinoma cell apoptosis. They determined that cannabidiol significantly inhibited cell viability.

Blood Cancer

15 – A study published in the journal Molecular Pharmacology recently showed that cannabinoids induce growth inhibition and apoptosis in matle cell lymphoma. The study was supported by grants from the Swedish Cancer Society, The Swedish Research Council and the Cancer Society in Stockholm.

16 – A study published in the International Journal of Cancer also determined and illustrated that cannabinoids exert antiproliferative and proapoptotic effects in various types of cancer and in mantle cell lymphoma.

17 – A study published in the US National Library of Medicine conducted by the Department of Pharmacology and Toxicology by Virginia Commonwealth University determined that cannabinoids induce apoptosis in leukemia cells.

Oral Cancer

18 – A study published by the US National Library of Medicine results show cannabinoids are potent inhibitors of cellular respiration and are toxic to highly malignant oral Tumours.

Liver Cancer

19 – A study published by the US National Library of Medicine determined that that THC reduces the viability of human HCC cell lines (Human hepatocellular liver carcinoma cell line) and reduced the growth.

Pancreatic Cancer

20 – A study published in The American Journal of Cancer determined that cannabinoid receptors are expressed in human pancreatic tumor cell lines and tumour biopsies at much higher levels than in normal pancreatic tissue. Results showed that cannabinoid administration induced apoptosis. They also reduced the growth of tumour cells, and inhibited the spreading of pancreatic tumour cells.

Sources: 

All sources highlighted throughout article. Click on the highlighted parts of the article to view them.

1)http://bjp.rcpsych.org/content/178/2/116.full

Cannabis OIL Cancer Cure: Dr. Raphael Mechoulam discusses medical cannabis. From marijuana nation.

Source: http://420insight.com/research/medical-stu...

The Entourage Effect with Video Demonstration....

This article was taken from leafscience.com, September 11, 2014.

The interaction of various compounds in marijuana is known as the ‘entourage effect.  The‘entourage effect’ was a term coined by Dr. Ethan Russo, who, in 2011, published a paper in the British Journal of Pharmacology describing the synergistic contributions of other compounds in cannabis. A very interesting video is shown below to demonstrate the effect.

Here’s how it works.

Marijuana, unlike most modern day medicine, contains a wide range of chemical compounds. Scientists have identified over 60 unique molecules in cannabis known as cannabinoids, which include THC and CBD. Many other non-cannabinoid compounds are produced by the plant that also have regulatory effects.

For example, terpenes, the molecules responsible for marijuana’s smell, have been shown to block some cannabinoid receptor sites in the brain while promoting cannabinoid binding in others. As a result, terpenes are believed to affect many aspects of how the brain takes in THC or CBD, while offering various therapeutic benefits of their own.

In fact, while THC has gotten most of the attention, studies suggest many of the compounds in marijuana work together to produce a synergy of effects. This is known as the ‘entourage effect.’

Understanding Strains

Marijuana comes in thousands of different varieties, or strains. Different marijuana strains have vastly different chemical profiles that cause different experiences in the same person.

This explains why sometimes marijuana can make a person feel calm, while other times it can make that same person feel anxious or paranoid.

The chemical components of marijuana include, but are not limited to, terpenes, ketones, esters, lactones, alcohols, fatty acids, and steroids. The effects of all these chemicals working together and regulating each other will be much different than the effects of any one chemical working alone.

In other words, marijuana is made up of thousands of different chemicals that work together to produce some general effect. Change the recipe and you change the effect.

The Entourage Effect — An Example

One of the starkest examples of the entourage effect was a British study that gave patients pure THC intravenously one day, and then a mixture of THC and CBD intravenously a week later.

Nicky Taylor, the host of the BBC documentary “Should I Smoke Dope?,” participated in the study and filmed it for the world to see:

Intravenous THC & CBD Experiment

Although she kept referring to cannabidiol (CBD) inaccurately as “cannabinoid,” the end result was so illustrative of the entourage effect that it’s hard to be too annoyed.

In the video, she reported feeling horrible with just THC, “like being at a funeral.” Yet with the THC/CBD mixture, she was unable to contain her laughter throughout the session. THC and CBD appeared to interact somehow, which has been shown by other studies as well.

Incidentally, she was kept blind to which cannabinoid mixture she was given.

Source: http://www.leafscience.com/2014/09/11/medi...