Whole plant CBD extract vs. synthetic single molecule

Back in February of this year a excellent Israeli study was done documenting the superior therapeutic properties of whole plant CBD-rich Cannabis extract as compared to synthetic, single-molecule cannabidiol (CBD) which is made in the lab. The notion that botanical extracts are "low grade and crude" as opposed to pure single molecule synthetic compounds made by the pharmaceutical companies is what was challenged. The study was Published in the journal Pharmacology & Pharmacy (Feb. 2015).

The study showed that administration of pure, single-molecule CBD resulted in a bell-shaped dose-response curve, that means when the amount of CBD exceeded a certain point its therapeutic impact declined dramatically. “Healing was only observed when CBD was given within a very limited dose range, whereas no beneficial effect was achieved at either lower or higher doses,” the authors observed. This characteristic of single-molecule CBD—manifested as a bell-shaped dose response—imposes serious obstacles that limit its usefulness in a clinical context.

The Israeli team sought to determine whether the administration of a whole plant CBD-rich extract would also generate a bell-shaped dose-response curve when administered to mice. Or would cannabidiol extracted from CBD-rich Cannabis avoid this liability? But a different dose response pattern was observed when the whole plant extract was administered to mice. Rather than showing a bell-shaped curve, where a therapeutic effect could only be achieved at a certain concentration of pure CBD, the whole plant CBD-rich extract caused a direct, dose-dependent inhibition of pain, inflammation, and TNFa production.

Moreover, the Israeli researchers found that a small amount of CBD in the whole plant extract was needed for significant pain relief compared to the much larger amount of pure single molecule CBD required to achieve the same analgesic effect. And whereas pure, single-molecule CBD precipitated a dramatic drop in efficacy if more than a specific dosage was administered, an “overdose” of whole plant CBD-rich extract did not undermine its therapeutic potency.

The body recognizes and can utilize substances that are natural, from nature. That is how we are made.  Anything that is synthetic is hard for the body to know what to do with it, yes, it can have an effect but in my opinion not as great an effect. The whole plant has not only cannabinoids, but terpenes and flavinoids and many other compounds which all work together synergistically and have positive effects in the body.

We here at Pianta Tinta are proud of our High CBD tincture in that we use the whole plant to extract out as much cannabinoids and other compounds to make the best medicine we can!

The above is just a small portion of the study done, if you wish to read the actual study click here.

A thank you to projectcbd.org for originally posting the article!

Elizabeth Knight, Pianta Tinta

 

Rossmoor Seniors Fired up about Cannabis....

Recently I attended an event at Rossmoor, in Walnut Creek. Little did I know that they have a senior community of 10,000. How great it was to see acceptance, education and people TALKING about medical cannabis!! There was a report on site, Joe Garofoli and this is the article that came out in the SF Chronicle.

by Joe Garofoli

Updated 1:59 pm, Tuesday, April 21, 2015

Doug Stiles shows a bottle of liquid cannabis in his home at the Rossmoor retirement community in Walnut Creek. Stiles takes 20 drops before bed to help with his anxiety and help him sleep.

Pot was for fun in Rossmoor resident Doug Stiles’ youth. Now he takes it in liquid form to ease anxiety and help him sleep.

There is a club for Bay Area marijuana enthusiasts where most members don’t want to get high. Mostly because they’re afraid of falling. Or getting too disoriented.

The club is in Rossmoor, the senior citizen community of 10,000 near Walnut Creek.

With an average age of 76, Rossmoor is the kind of place where smoking is banned, though many puff cigars in plain sight on the golf course. But before the Rossmoor Medical Marijuana Education and Support Club held its first meeting in 2011, marijuana was rarely seen, smelled or discussed on the facility’s surgically trimmed grounds.

Since then, the club has grown into a 250-member juggernaut, illustrating the growing acceptance of marijuana in America by seniors — and their growing frustration with mainstream pharmaceuticals prescribed for pain relief.

In 1986 — the heyday of the nation’s War on Drugs — 9 percent of the generation of Americans born between 1928 and 1945 supported legalizing marijuana. That has jumped to 29 percent among that demographic, according to a Pew Research report released this month.

The survey also showed that it might be time to dig through Grandpa’s golf bag: 19 percent of Americans over 70 have tried weed, including 2 percent in the last year.

That might be an undercount, according to some Rossmoor weed aficionados. Many residents are cultivating more than azaleas at home.

“Oh, sure, I’ve got a plant. A lot of people here do,” one woman said after a club meeting last week in Rossmoor. “But I can’t give you my name.”

Changing times

That’s a common sentiment. One club member asked to remain anonymous because “my son owns a business near here.” A few still haven’t told their kids they’re members because they have spent the last 50 years telling them not to smoke dope.

Perhaps because of the reluctance of seniors to discuss their marijuana habits, neither AARP nor the Marijuana Policy Project could provide any studies of cannabis use by seniors. AARP doesn’t have a policy on medical cannabis, even though it is now legal for medicinal use in 23 states and Washington, D.C.

Appropriately, it was on a Rossmoor golf course where the club held its first clandestine meeting four years ago. Twenty cannabis-curious pioneers set up folding chairs near the first tee box at 4 p.m., when they knew most of their golfing neighbors would have already left for cocktail hour, which, like many things in Rossmoor, starts a little early.

“People were still not sure if they wanted to be out about (marijuana) then,” said Renee Lee, a 63-year-old retired therapist who is president of the club. “There was still a stigma about it.”

Lee was among those who wanted to call themselves the 420 Club, but that reference to the weed smokers’ holiday of April 20 never stuck because, as Lee said, “a lot of people didn’t know what it meant.”

They went six months without a name. But club members quickly bonded over their shared disappointment in pharmaceuticals they had been prescribed. Either the pills weren’t helping them or the side effects were more onerous than their actual ailments.

Their knees and elbows and backs creaked. They had trouble sleeping. They were anxious. All they wanted was some relief.

So why not try a little pot?

Highly recommended

Sometimes it was their adult children who suggested it. More often the notion came from a medical-cannabis-card-carrying neighbor, who would offer a weed-infused lemon drop or a dab of a topical cream. It was a leap of faith for seniors who never tried pot — or hadn’t indulged since the Kingston Trio was topping the charts.

“The most common thing they say is, 'I’m not doing this to get high,’” said Rachna Patel, a Walnut Creek osteopath who has treated about 100 Rossmoor residents who use cannabis for pain relief. “A lot of them will first say, 'I can’t believe that I’m doing this.’”

But many are soon smiling at the results. Doug Stiles hadn’t partaken in years until he moved to Rossmoor about four years ago. Then he started rubbing a cannabis-infused topical solution into his wife’s knees to help with her arthritis. Four months later, she was moving more easily. Now Stiles takes cannabis-infused drops at night to soothe his anxiety and help him sleep.

Back in the day

That’s not how he used marijuana during his occasional indulgences as a young man.

“I remember at a party smoking with a brother-in-law, then going out to the liquor store. But we had to pull over in the park because we were laughing so hard,” Stiles said. But “now it’s about pain — and feeling better.”

What initially “surprised me,” said Eloise Theisen, a nurse practitioner in Lafayette who helps dozens of Rossmoor residents manage their health conditions with cannabis, “is how open they’ve been to trying new things.”

But club members aren’t your typical stoners. “Everybody always shows up 15 minutes early for the meetings,” said Lee, who used cannabis to help her with the aftereffects of acoustic neuroma surgery.

Dozens of Rossmoorians are now smoking or vaping or nibbling at edibles, mostly in the quiet of their homes.

Just for fun

Nobody smells weed outside. Unless maybe it’s coming from members of Rossmoor’s other cannabis club — a group focused less on education and support and more on enjoying the herb’s recreational pleasures. Unlike the Rossmoor Medical Marijuana Education and Support Club, the other group is not officially recognized by the administration.

The harder question for some is one that’s rarely been uttered in the half-century history of this 1,800-acre enclave: How can I score some weed in Rossmoor?

Medical cannabis dispensaries are banned in Walnut Creek, and there are few east of the Caldecott Tunnel.

And forget getting pot through that newfangled smartphone technology. The app-based marijuana delivery service Eaze — which promises cannabis within minutes for card-carrying Bay Area users — said only 2 percent of customers are seniors. Eaze is launching a pilot program with a San Diego senior community to learn how to make it easier for seniors to get deliveries.

'Untapped market’

“There’s definitely an untapped market there,” said Eaze spokeswoman Caroline Vespi. “There’s still that perception among some seniors that the only place you can get (cannabis) is from the dealer on the corner.”

After accepting an invitation to speak to the club a couple of years ago, the Harborside Health Center arranged for a tour of the Oakland medical cannabis dispensary. Now it counts dozens of Rossmoor residents as customers.

But nurse practitioner Theisen said venturing unaccompanied into a dispensary can be overwhelming for some seniors.

So, many Rossmoor residents get their weed from what once might have been an unlikely source: their grown children. State law allows medical cannabis patients to designate someone as a caregiver.

As the general public’s attitude toward marijuana has warmed over the past few years, the club’s membership has swelled, and some of the region’s top cannabis figures have appeared before them.

Last week’s meeting drew a record 81 members to hear John Malanca, founder of United Patients Group, a website that offers news and information about medical cannabis.

“How many people here think the only way to take marijuana is to smoke it?” Malanca asked the audience.

Not a hand went up.

“Wow,” Malanca said, rocking back a step. “When I was here a few years ago, 60 percent of the people raised their hands.”

After the meeting ended, Malanca said, “When I asked that, people just looked at me like, 'That was the most boneheaded question.’ But that’s why when I visit retirement communities around the country, I tell them about the amazing things going on at Rossmoor.”

Orange County aficionados

But while Rossmoorians are becoming weed sophisticates, they still lag behind their demographic peers at the Laguna Woods Village — formerly known as Leisure World — in Orange County. Cannabis-using residents there have established a relationship with a Humboldt County grower and created a distribution network in the community that has the administration’s blessing.

Down there, if Laguna Woods Village Cannabis Club organizer Lonnie Painter wants to smoke a joint outside his residence, he just sparks one up.

“Oh, sure,” said Painter, a 69-year-old retired restaurateur. “I do that almost daily.”

Joe Garofoli is a San Francisco Chronicle staff writer. E-mail: jgarofoli@sfchronicle.com Twitter: @joegarofoli

Source: http://www.sfgate.com/bayarea/article/Ross...

Traveling with Cannabis???

United Patient Group website recently had an article on traveling with Cannabis. This has been a question for some of our members and I thought it would be a good idea to post the article in full. So wherever you are traveling to, do some research ahead of time to find out the specific laws for the states, countries that you will be visiting......

 

Traveling with Medical Marijuana

It can be a challenge to travel for medical marijuana patients. In addition to concerns brought on by their condition, traveling with medical marijuana can be difficult, especially for out of state trips. Even in certain areas of the country, in-state travel can present problems when local ordinances vary. Patients should consider the following factors before traveling with their medication.

 

 

 

Traveling Within the Same State

Medical marijuana patients who are appropriately registered with their state should not encounter problems if they are traveling locally. Patients may have their medication on their person when they are walking and driving within their own county. For out-of-county trips, patients should be aware that some counties set their own laws regarding maximum medical marijuana amounts, though, in California, all counties must allow at least the state minimum. Patients should know their state’s laws and, as a rule of thumb, avoid traveling to unfamiliar areas with more than the allowed minimum.

If a patient is traveling out-of-county and the state’s recognized minimum is not sufficient, it may be possible to arrange temporary dispensary privileges in the area where the patient is staying. Patients should ask the dispensary they are currently using for advice, or check their state's website for the rules.

Whether in state or out of state, medical marijuana patients should never travel with marijuana plants. Even in states where it is legal to grow medical marijuana plants, their transportation is highly restricted. In California, for example, there are only three situations where it is appropriate to travel with these plants:

 

  • When a patient or caregiver is bringing plants from a dispensary to a residence.
  • When a registered caregiver is moving plants from one patient’s residence to another.
  • When a patient is moving residences.

Except for these situations, avoid traveling with medical marijuana plants to minimize the chance of legal complications.

 

 

 

Out of State Trips

Travel to different states for medical marijuana patients is difficult because they cannot legally bring their medical marijuana in most cases. Patients should note these guidelines:

 

  • States without medical marijuana laws can arrest patients under possession laws, even if the patient is registered in their home state.
  • Federal authorities can arrest patients under federal drug trafficking laws if medical marijuana crosses state lines.
  • In states that recognize medical marijuana cards issued by the patient’s home state (called reciprocity), the patient usually still needs to register in the state that they are visiting and acquire any medical marijuana needed there, rather than bringing it with them.
  • In the above situation if patients plan to bring their own medical marijuana, they should make sure that the states border one another so that they are not traveling through states where medical marijuana is illegal.

 

 

 

Traveling by Ground vs. Flying with Medical Marijuana

The safest mode of transportation for traveling patients is by car. Private bus and train companies may remove passengers at their own discretion who appear under the influence or are known to possess medical marijuana, even with a medical marijuana card or valid physician’s letter.

As for flying, airports and airplanes are federal jurisdictions, and patients can be detained and arrested when going through security. Federal authorities do not recognize the medical marijuana laws or cards of any state. There are some airports that are medical marijuana ‘friendly’ and allow patients with correct documents to board with the amount deemed necessary for personal consumption. 

For more detailed information on this, read our article: Can I Fly with Medical Marijuana? 

Always check the laws of your home state and the state that you will be visiting before taking a trip with your medication. Though it is very helpful to patients, medical marijuana is not yet legal in all areas and even in states where medicinal use of marijuana is legal, state and local laws vary. Know your rights and responsibilities as a patient, and always ask an authority if you are unsure of the law.

 

For more information on Flying with Medical Marijuana, here is a direct link to TSA's policy.

Source: http://www.unitedpatientsgroup.com/resourc...

Cannabis Dosing: Doctors Weigh In

Here is a great article from United Patients Group in which 3 Doctors using Medical Cannabis in their practices have seen similar trends in dosing and results..."How much should I take?" This is a question that comes up often and although dosing is an individual issue, these Doctors have worked with enough patients to see what is working.......

Elizabeth

Doctors Weigh In – Medical Cannabis Dosing: Why Less May Be More

Posted on March 18, 2015 by UnitedPatientsGroup.com

Many medical cannabis patients take an overly aggressive approach to treatment. If one hit off a joint or one square of chocolate helps a little, then a whole joint or a whole chocolate bar will help a lot, right? Not quite. In many cases, while taking in ‘more‘ cannabis will make you ‘more‘ high, it won’t necessarily make you ‘more‘ healthy. In fact, reducing your dosage may actually make it ‘more‘ effective.

Dr. Dustin Sulak, the Medical Director of Integr8 Health, LLC, a network of three (3) holistic health clinics in New England, where he and his colleagues treat nearly 20,000 patients with medical cannabis as part of an integrative medicine approach to health, have found that many of his patients benefit more from low doses—they have better results and fewer side effects.

“When I started my practice, I was surprised to see that some patients were using very low dosages (e.g. 1 puff), while other patients require much higher dosages (e.g. 1 joint or a potent edible) to achieve optimal benefits,” notes Dr. Sulak. “Over time, I began to notice that most patients using small amounts of cannabis were getting better and more sustainable results than their high-dosage counterparts with similar conditions. Eventually I discovered that most people have a certain threshold dosage of cannabis, below which they’ll actually experience a gradual increase in health benefits over time, and above which they’ll start building tolerance, experiencing diminishing benefits, and more side effects.”

Preclinical research supports these observations, demonstrating that administration of cannabinoids can upregulate endocannabinoid system function at acute and lower doses via increased endocannabinoid production[i], cannabinoid receptor expression[ii], and cannabinoid receptor affinity[iii], as well as downregulate endocannabinoid system function upon persistent agonism (e.g. long-term high doses) via membrane receptor endosome internalization[iv]. This dosing phenomenon is known as a biphasic dose-response curve.

Dr. Sulak has moved many patients down to doses as low as 3–5 mg with his “sensitization protocol,” which helps current users to reset their endocannabinoid system. After just six days on the protocol, 90 percent of patients can decrease their dosage with improved benefits. His patients have an average reduction of 56 percent.

“This reduction not only improves benefits and reduces side effects – it saves patients a lot of money, and potentially makes more cannabis available for those with limited access,” says Dr. Sulak.

Dr. Bonni Goldstein, Medical Director of Canna-Centers, located throughout California, has noticed similar results with her patients. “Many of my patients using low doses for pain, mood, and sleep find that low doses give the effects they are looking for, and over time, due to the enhancement of their endocannabinoid system, they find that they don’t need as much phytocannabinoids to achieve the desired effects.”

Her observations are backed by a study from the Medicinal Cannabis Research Center at the University of California, San Diego, that tested vaping cannabis to treat neuropathic pain. The results showed that patients who used small-dose cannabis (1.29 percent) felt as much pain relief as patients who used medium-dose (3.53 percent) cannabis.

Why might this be? The functioning of the body’s endocannabinoid system, and its interaction with phytocannabinoids (from the cannabis plant), is not yet fully understood—marijuana’s quasi-legal status makes this difficult to study. Dr. Sulak and Dr. Goldstein both hypothesize that small doses of phytocannabinoids enhance the endocannabinoid system, while larger doses cause the system to down-regulate, making the receptors less responsive.

“Cannabinoids are bi-modal effects,” explains Dr. Allan Frankel, CEO of GreenBridge Medical Services in Santa Monica. “This means that in general, low dose and high dose can have opposite effects.”

He points to studies by GW Pharmaceuticals, makers of Sativex, that show better results from low or medium doses than high doses. One study of cancer patients found that low doses (1–4 sprays per day) resulted in statistically significant reductions in pain and sleep disruption, while high doses (11–16 sprays per day) did not result in better outcomes but did cause a much higher dropout rate (22 percent, versus 5 percent in the low-dose group).

Cancer patients are typically treated with extremely high doses of cannabis, but Dr. Frankel questions the wisdom behind this  approach.

“I have seen at least 7 patients with stage IV cancer who initially responded to RSO dosing [Rick Simpson Oil, which is often dosed as high as a gram per day] and then had new metastases, went on low dose CBD:THC and had clearing of metastases.”

He points out that nobody knows what “dose” or regimen is “best” for cancer. “In fact,” says Dr. Frankel, “probably a number of different cannabinoid ratios and doses for certain have anti-cancer effects through a multitude of mechanisms.” He says that, on average, across numerous ailments, his sickest patients use a dose of around 30–40 mg of cannabinoids—far lower than the RSO recommendation.

Dr. Sulak cautions that while he generally sees better results from lower doses, he has observed that about 10 percent of his patients only respond to very high doses—as much as 300–500 mg per dose.

He explains, “In general, patients with greater resilience and who are closer to balance in their physiology are more likely to succeed with lower dosages, while patients who have been sicker for longer sometimes may require aggressive dosing to control the disease process, then are able to convert to low dosages later, after they too are closer to health and balance.”


Dr. Sulak’s sources:

[i] Burstein, S, Hunter, S. 1995. “Stimulation of anandamide biosynthesis in N-18TG2 neuroblastoma cells by δ9-tetrahydrocannabinol (THC).” Biochemical pharmacology 49, no. 6: 855-858.

[ii] Cichewicz, D, Haller, V, Welch, S. 2001. “Changes in opioid and cannabinoid receptor protein following short-term combination treatment with Δ9-tetrahydrocannabinol and morphine.” Journal of Pharmacology and Experimental Therapeutics 297, no. 1: 121-127.

[iii] Oviedo, A, Glowa, J, Herkenham, M. 1993. “Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study.” Brain research 616, no. 1: 293-302.

[iv] Hsieh, C, et al. 1999. “Internalization and recycling of the CB1 cannabinoid receptor.” Journal of neurochemistry 73, no. 2: 493-501.


Source: http://www.unitedpatientsgroup.com/blog/

Mercola interviews Dr. Frankel on Medical Cannabis

I am posting this excellent article and video by Dr. Mercola that is from March 9th, 2014. If you are confused about what is medicine and what isn't, or cannabis versus hemp, strength and dosage, then please read on and take some time to watch the interview!! A big thank you to Dr. Joseph Mercola and the wonderful service he provides for those of us that choose holistic health care.....

Elizabeth

By Dr. Mercola

Marijuana has been legalized in a number of US states; 20 states have legalized cannabis for medical purposes; two states—Colorado and Washington state—also permit recreational use. Certain forms of cannabis are actually very potent medicine, with few or no psychoactive effects.

In California, medical marijuana has been legal for 18 years. Dr. Allan Frankel, a board-certified internist in California, has treated patients with medical cannabis for the past seven years.

By and large, cannabis is highly favored by people across the US. According to Dr. Frankel, 85-95 percent of Americans are in favor of medical cannabis, and 58-59 percent are in favor of legalizing marijuana.

The federal government, meanwhile, wants to get rid of all medical use of marijuana, which of course begs the question: Why? According to Dr. Frankel, the answer is simple. "They want it. This is a huge market," he says.

And yes, medical cannabis is clearly competition to the pharmaceutical industry, as the cannabis plant can take the place of a wide variety of synthetic drugs, especially for mood and anxiety disorders. The last thing they want is a therapy that's going to take away from their bottom line.

Cannabis as Medicine

Dr. Frankel initially learned about medical cannabis through glaucoma trials and cancer work performed at UCLA in the 70s and early 80s.

"I've always seen it as a medicine," he says. "Eventually, I got interested in it. I thought my tool box was getting too small for typical issues with patients related to anxiety, pain, or the common issues where we just had inadequate medications.

I saw the cannabinoid future was something that was bright. Seven years ago, I kind of picked up my formal white coat and sprayed a little green on it..."

Green Bridge Medical is his professional corporation where he sees patients, performs research, and provides physician and patient education and outreach. For all its benefits, using cannabis in lieu of other medicines has many challenges.

"It's a complicated process, as a physician in particular, working inside the medical system, to work outside the medical system to make these dose-consistent extracts available."

Many may find the idea of medical cannabis abhorrent or somehow "wrong," as we've been indoctrinated to view marijuana as a dangerous gateway drug that will lead you down a path of illicit drug use.

Many fail to realize that prescription drugs actually have FAR greater potential to turn you into "a junkie." Legal drug addiction is also taking lives in record numbers. In the UK, one million people are addicted to over-the-counter (OTC) and prescription painkillers and tranquilizers.

That's significantly more than the number addicted to illegal drugs.1 In the US, there were four times more deaths among women from prescription painkiller overdose than for cocaine and heroin deaths combined in 2010.2

Pharmaceuticals in general are among the leading causes of death in the US, and some medicines have killed tens of thousands of individuals. The painkiller Vioxx is one classic example, which killed over 60,000 before being pulled off the market.

The diabetes drug Avandia is another, and most recently, a study estimated that in a five-year span, some 800,000 people in Europe were killed from inappropriate use of beta-blockers in non-cardiac surgery patients. Deaths attributed to cannabis barely registers in comparison.

"I think that any intervention, regardless of how benign (I would say in my 35 years of medical experience, cannabis should be considered a benign substance overall), there are potential uses and abuses," Dr. Frankel says.

"For me, we're just talking about the real solid indications. The issue of abuse and neglect is there, but I think it's relatively small. I think the claim that it is a gateway drug has been pretty soundly proven not to be correct.

Even if cannabis to some extent is a gateway drug (which I do not believe it is), even if it is, it should be legalized to protect the gateway [drug] issue, because legalization opens up communication."

Natural health physician and Mercola.com founder Dr. Joseph Mercola interviews Dr. Allan Frankel about the medical uses of marijuana or cannabis.

What's the Difference Between Medical and Non-Medical Marijuana?

According to Dr. Frankel, cannabis has been cultivated in Northern Europe since before the last Ice Age. Even back then, there were two very distinct groups of strains. One is cannabis; the other is hemp. There's plenty of confusion about the similarities and differences between these two plants. While they are subspecies of the same plant species, they look very different, and are extremely different in ways that really matter when it comes to medicinal use.

The thing they have in common is that they both contain cannabidiol (CBD), which has medicinal properties. The amount of CBD however, differs greatly between the two. Dosing, therefore, is dramatically different where you to try to use hemp in lieu of cannabis, as the latter, cannabis, is up to 100-fold more potent. Another difference that appears to matter in terms of its usefulness as medicine relates to differing terpene profiles. Hemp contains very little of these valuable medicinal compounds.

Lastly, there's the tetrahydrocannabinol (THC) content. THC is the psychoactive component of marijuana; it's the molecule that makes you feel "stoned." (While cannabidiol (CBD) also has certain psychoactive properties, it does NOT produce a high.) By legal definition, hemp cannot have more than 0.3 percent tetrahydrocannabinol (THC) in it. So to summarize:

  • Hemp has less value for medicinal uses, as it only contains about four percent CBD and lacks many of the medicinal terpenes and flavonoids. It also contains less than 0.3 percent THC, which means it cannot produce a high or get you stoned. However, for many disease processes, THC is very much indicated and required. So, for many disease processes, CBD alone has much less value.
  • Cannabis is potent medicine courtesy of high amounts (about 10-20 percent) of CBD, critical levels of medicinal terpenes, and flavanoids, as well as THC in varying ratios for various diseases. The higher the THC, the more pronounced its psychoactive effects

How Marijuana Got a Bad Rap

"What happened in the '60s and '70s was that due to desires for psychedelia, the changes in the war in Vietnam, and the war on drugs with Nixon, the types of strains that were available and the demand for psychedelia changed. Before we knew it, CBD—due to a lack of 'stoniness'—was bred out of the plant," Dr. Frankel explains.

As a result of growers breeding out the all-important CBD, marijuana became known primarily as a plant that gets you high. Its original medicinal properties and uses largely fell by the wayside. Things are changing however.

"Five years ago, California Physicians, and other groups around the world, didn't really know if we would find CBD-rich strains anymore, but we have. Now there's many different varieties of it. We keep bringing back new CBD rich strains every month or two. These plants genes' haven't seen the light of day for God knows how long."

CBD is currently a Schedule 1 controlled substance, which means:

  • The drug or other substance has a high potential for abuse
  • The drug or other substance has no currently accepted medical use in treatment in the US
  • There is a lack of accepted safety for use of the drug or other substance under medical supervision

There's no doubt that CBD needs to be rescheduled, as each of these three points are blatantly wrong. Dr. Frankel actually thinks cannabis should be de-scheduled altogether, as a plant really does not belong on any schedule of a controlled substance.

"How could we have a plant on a schedule? What if it's an all-THC plant? What if it's an all-CBD? What if we find some other psychoactivity? If you take the Physicians' Desk Reference (PDR) and look at every product, none of them looks like a plant to me. This is the only plant, and it's not just one medicine. One entry with one data ID or MDI cannot be applied for cannabis. For example, we're actually right now making different medicines with cannabis plants based upon harvest time.

As the plants mature, the flowers get darker and darker. There's a traditional time when you're just supposed to pick them. Of course, what we've done is we picked them at different times in large amounts, ground them all together so we can get very representative samples, and see what happens in the last few weeks of flowering. The medicine changes a lot in the last three weeks. You can make more sedating medicine by letting it just stay on the vine three weeks longer. Even how long you let it grow makes it a very different medicine, a noticeably different medicine," he says.

Who's a Good Candidate for Medical Cannabis?

In his medical practice, Dr. Frankel treats a wide variety of patients with medical cannabis, which has become his specialty. Despite the many claims of cannabis performing miracles, he's reluctant to think of it as a cure for anything. Occasionally, however, patients will experience very dramatic results. For example, he has seen tumors virtually disappear in some patients using no other therapy except taking 40 to 60 milligrams of cannabinoids a day. The most common thing he sees in cancer patients, however, are tumors shrinking, or a metastasis disappearing. Sometimes tumors will shrink or vanish, only to reemerge in other areas, months later, and then shrink or vanish again... Other common ailments being treated with cannabis include:

  • Mood disorders
  • Pain disorders
  • Degenerative neurological disorders such as dystonia
  • Multiple sclerosis
  • Parkinson's disease
  • PTSD
  • Seizure Disorders

He recounts how two dystonia patients with severe myofascial spasms were able to return to normal life after taking two milligrams of whole-plant CBD three times a day for a little more than one week. This is quite astounding, considering each of them had spent more than a decade undergoing neurosurgeries and taking multiple medications.

Dr. Frankel is very focused on trying to develop accurate dose-consistent medicine. The Patient Access Centers he consults with create a diverse collection of dose-consistent oral-buccal sprays. He also believes it's very important to open up and start talking about dosing—what works, what doesn't. It is his belief that some patients, in large part due to lack of education about the medicine, may be taking 10, or even 100 times higher dosage than is really needed to treat their ailment. Unfortunately, many doctors in this still highly controversial field are afraid to recommend dosages, for fear of the repercussions.

"There's this false notion (I think I can very safely say it's false) that doctors cannot recommend dosage because of this federal [law against] aiding and abetting with cannabis. It's not true. It's just not true," he says. "There are no [cannabis] medications that we dose by body weight. We now have about 120 kids with seizure disorder, and if you look at the surveys, across the board, the average dose is 37 milligrams [of whole-plant CBD] per day, and there's no relationship with body size."

More Information

A British pharmaceutical company called GW Pharmaceuticals has a cannabis product that is distributed in Canada and five other countries. It's a 1:1 CBD-THC whole plant extract. "It's a very good medicine," Dr. Frankel says. "But it's expensive. That's the problem with pharmaceutical [companies]." Dr. Frankel also consults with various states that are interested in growing medicinal CBD, i.e. cannabis with a high CBD content and hemp-level (extremely low) THC. He even gives the CBD seeds away. "I make the offer: if any governor in the 50 states wants, absolutely free – as long as I can do it legally – any of these high-ratio CBD strains, I can make it happen. No cost," he says.

"This is one of the important points I'd to emphasize: I think we're going to find ultimately that CBD is a nutritional supplement for everybody. I think we were all using [cannabis] 100 years ago... I think then, if they had hemp for food, there was CBD in it. Again, I wasn't there, but my guess is that everybody had CBD in their diet up until 100 years ago or so. CBD appears in some of the newest data to help protect your DNA epigenetic layer. That's important stuff for all of the toxins that we have in our environment. I think we have more toxins now, and we're missing one of the major protectants that we used to use for this. That's a double whammy."

Source: http://articles.mercola.com/sites/articles...

Not all CBD tinctures are the same!!

Tinctures offer the best way to deliver nutrients in stable soluble form, optimal for assimilation. Tinctures retain volatile and semi volatile ingredients, usually lost in heat treated and especially reprocessed dry extracts. The importance of these ingredients for health beneficial action is hard to overestimate.

Due to convenient dosing, tinctures are one of the safest herbal preparations on the market

One of the things that people overlook when buying a High CBD tincture or oil is what is on the label! Make sure that the CBD content is listed so that you know how much of it you are getting and if you are paying a fair price. In liquid the CBD is measured in mg per ml. There is approximately 30 ml of liquid in a 1 fl oz bottle. If the label says for instance that there is 3 mg per ml of CBD, then there is a total of 90mg of CBD in that 1 oz bottle.  Some companies charge a high price for a very low amount of CBD content so it is important to shop around. With a higher quality tincture with a higher CBD content per bottle (250-300 mg) would mean you can take less of the product and get great results. 

Another number to look at is the ratio between the CBD and THC. Our tincture has a 22:1 ratio meaning there is 22 times more CBD than THC!

  1. Consider the condition you’re treating. For anxietydepressionspasms, and pediatric seizure disorders, you may do better with a moderate dose of a CBD-dominant remedy—look for a CBD:THC ratio of more than 14:1. For cancer or pain, you may need more THC, for instance, a 1:1 ratio.

So, just because a product says High CBD on the label, or Ultra High CBD, don't assume that's what it is.... Do a little research on your own and make sure they list the test results either on their label or on their website!!  It's a bit like our food industry, some labels say the product is all natural yet it is filled with junk!!