Mercola interviews Dr. Frankel on Medical Cannabis

I am posting this excellent article and video by Dr. Mercola that is from March 9th, 2014. If you are confused about what is medicine and what isn't, or cannabis versus hemp, strength and dosage, then please read on and take some time to watch the interview!! A big thank you to Dr. Joseph Mercola and the wonderful service he provides for those of us that choose holistic health care.....

Elizabeth

By Dr. Mercola

Marijuana has been legalized in a number of US states; 20 states have legalized cannabis for medical purposes; two states—Colorado and Washington state—also permit recreational use. Certain forms of cannabis are actually very potent medicine, with few or no psychoactive effects.

In California, medical marijuana has been legal for 18 years. Dr. Allan Frankel, a board-certified internist in California, has treated patients with medical cannabis for the past seven years.

By and large, cannabis is highly favored by people across the US. According to Dr. Frankel, 85-95 percent of Americans are in favor of medical cannabis, and 58-59 percent are in favor of legalizing marijuana.

The federal government, meanwhile, wants to get rid of all medical use of marijuana, which of course begs the question: Why? According to Dr. Frankel, the answer is simple. "They want it. This is a huge market," he says.

And yes, medical cannabis is clearly competition to the pharmaceutical industry, as the cannabis plant can take the place of a wide variety of synthetic drugs, especially for mood and anxiety disorders. The last thing they want is a therapy that's going to take away from their bottom line.

Cannabis as Medicine

Dr. Frankel initially learned about medical cannabis through glaucoma trials and cancer work performed at UCLA in the 70s and early 80s.

"I've always seen it as a medicine," he says. "Eventually, I got interested in it. I thought my tool box was getting too small for typical issues with patients related to anxiety, pain, or the common issues where we just had inadequate medications.

I saw the cannabinoid future was something that was bright. Seven years ago, I kind of picked up my formal white coat and sprayed a little green on it..."

Green Bridge Medical is his professional corporation where he sees patients, performs research, and provides physician and patient education and outreach. For all its benefits, using cannabis in lieu of other medicines has many challenges.

"It's a complicated process, as a physician in particular, working inside the medical system, to work outside the medical system to make these dose-consistent extracts available."

Many may find the idea of medical cannabis abhorrent or somehow "wrong," as we've been indoctrinated to view marijuana as a dangerous gateway drug that will lead you down a path of illicit drug use.

Many fail to realize that prescription drugs actually have FAR greater potential to turn you into "a junkie." Legal drug addiction is also taking lives in record numbers. In the UK, one million people are addicted to over-the-counter (OTC) and prescription painkillers and tranquilizers.

That's significantly more than the number addicted to illegal drugs.1 In the US, there were four times more deaths among women from prescription painkiller overdose than for cocaine and heroin deaths combined in 2010.2

Pharmaceuticals in general are among the leading causes of death in the US, and some medicines have killed tens of thousands of individuals. The painkiller Vioxx is one classic example, which killed over 60,000 before being pulled off the market.

The diabetes drug Avandia is another, and most recently, a study estimated that in a five-year span, some 800,000 people in Europe were killed from inappropriate use of beta-blockers in non-cardiac surgery patients. Deaths attributed to cannabis barely registers in comparison.

"I think that any intervention, regardless of how benign (I would say in my 35 years of medical experience, cannabis should be considered a benign substance overall), there are potential uses and abuses," Dr. Frankel says.

"For me, we're just talking about the real solid indications. The issue of abuse and neglect is there, but I think it's relatively small. I think the claim that it is a gateway drug has been pretty soundly proven not to be correct.

Even if cannabis to some extent is a gateway drug (which I do not believe it is), even if it is, it should be legalized to protect the gateway [drug] issue, because legalization opens up communication."

Natural health physician and Mercola.com founder Dr. Joseph Mercola interviews Dr. Allan Frankel about the medical uses of marijuana or cannabis.

What's the Difference Between Medical and Non-Medical Marijuana?

According to Dr. Frankel, cannabis has been cultivated in Northern Europe since before the last Ice Age. Even back then, there were two very distinct groups of strains. One is cannabis; the other is hemp. There's plenty of confusion about the similarities and differences between these two plants. While they are subspecies of the same plant species, they look very different, and are extremely different in ways that really matter when it comes to medicinal use.

The thing they have in common is that they both contain cannabidiol (CBD), which has medicinal properties. The amount of CBD however, differs greatly between the two. Dosing, therefore, is dramatically different where you to try to use hemp in lieu of cannabis, as the latter, cannabis, is up to 100-fold more potent. Another difference that appears to matter in terms of its usefulness as medicine relates to differing terpene profiles. Hemp contains very little of these valuable medicinal compounds.

Lastly, there's the tetrahydrocannabinol (THC) content. THC is the psychoactive component of marijuana; it's the molecule that makes you feel "stoned." (While cannabidiol (CBD) also has certain psychoactive properties, it does NOT produce a high.) By legal definition, hemp cannot have more than 0.3 percent tetrahydrocannabinol (THC) in it. So to summarize:

  • Hemp has less value for medicinal uses, as it only contains about four percent CBD and lacks many of the medicinal terpenes and flavonoids. It also contains less than 0.3 percent THC, which means it cannot produce a high or get you stoned. However, for many disease processes, THC is very much indicated and required. So, for many disease processes, CBD alone has much less value.
  • Cannabis is potent medicine courtesy of high amounts (about 10-20 percent) of CBD, critical levels of medicinal terpenes, and flavanoids, as well as THC in varying ratios for various diseases. The higher the THC, the more pronounced its psychoactive effects

How Marijuana Got a Bad Rap

"What happened in the '60s and '70s was that due to desires for psychedelia, the changes in the war in Vietnam, and the war on drugs with Nixon, the types of strains that were available and the demand for psychedelia changed. Before we knew it, CBD—due to a lack of 'stoniness'—was bred out of the plant," Dr. Frankel explains.

As a result of growers breeding out the all-important CBD, marijuana became known primarily as a plant that gets you high. Its original medicinal properties and uses largely fell by the wayside. Things are changing however.

"Five years ago, California Physicians, and other groups around the world, didn't really know if we would find CBD-rich strains anymore, but we have. Now there's many different varieties of it. We keep bringing back new CBD rich strains every month or two. These plants genes' haven't seen the light of day for God knows how long."

CBD is currently a Schedule 1 controlled substance, which means:

  • The drug or other substance has a high potential for abuse
  • The drug or other substance has no currently accepted medical use in treatment in the US
  • There is a lack of accepted safety for use of the drug or other substance under medical supervision

There's no doubt that CBD needs to be rescheduled, as each of these three points are blatantly wrong. Dr. Frankel actually thinks cannabis should be de-scheduled altogether, as a plant really does not belong on any schedule of a controlled substance.

"How could we have a plant on a schedule? What if it's an all-THC plant? What if it's an all-CBD? What if we find some other psychoactivity? If you take the Physicians' Desk Reference (PDR) and look at every product, none of them looks like a plant to me. This is the only plant, and it's not just one medicine. One entry with one data ID or MDI cannot be applied for cannabis. For example, we're actually right now making different medicines with cannabis plants based upon harvest time.

As the plants mature, the flowers get darker and darker. There's a traditional time when you're just supposed to pick them. Of course, what we've done is we picked them at different times in large amounts, ground them all together so we can get very representative samples, and see what happens in the last few weeks of flowering. The medicine changes a lot in the last three weeks. You can make more sedating medicine by letting it just stay on the vine three weeks longer. Even how long you let it grow makes it a very different medicine, a noticeably different medicine," he says.

Who's a Good Candidate for Medical Cannabis?

In his medical practice, Dr. Frankel treats a wide variety of patients with medical cannabis, which has become his specialty. Despite the many claims of cannabis performing miracles, he's reluctant to think of it as a cure for anything. Occasionally, however, patients will experience very dramatic results. For example, he has seen tumors virtually disappear in some patients using no other therapy except taking 40 to 60 milligrams of cannabinoids a day. The most common thing he sees in cancer patients, however, are tumors shrinking, or a metastasis disappearing. Sometimes tumors will shrink or vanish, only to reemerge in other areas, months later, and then shrink or vanish again... Other common ailments being treated with cannabis include:

  • Mood disorders
  • Pain disorders
  • Degenerative neurological disorders such as dystonia
  • Multiple sclerosis
  • Parkinson's disease
  • PTSD
  • Seizure Disorders

He recounts how two dystonia patients with severe myofascial spasms were able to return to normal life after taking two milligrams of whole-plant CBD three times a day for a little more than one week. This is quite astounding, considering each of them had spent more than a decade undergoing neurosurgeries and taking multiple medications.

Dr. Frankel is very focused on trying to develop accurate dose-consistent medicine. The Patient Access Centers he consults with create a diverse collection of dose-consistent oral-buccal sprays. He also believes it's very important to open up and start talking about dosing—what works, what doesn't. It is his belief that some patients, in large part due to lack of education about the medicine, may be taking 10, or even 100 times higher dosage than is really needed to treat their ailment. Unfortunately, many doctors in this still highly controversial field are afraid to recommend dosages, for fear of the repercussions.

"There's this false notion (I think I can very safely say it's false) that doctors cannot recommend dosage because of this federal [law against] aiding and abetting with cannabis. It's not true. It's just not true," he says. "There are no [cannabis] medications that we dose by body weight. We now have about 120 kids with seizure disorder, and if you look at the surveys, across the board, the average dose is 37 milligrams [of whole-plant CBD] per day, and there's no relationship with body size."

More Information

A British pharmaceutical company called GW Pharmaceuticals has a cannabis product that is distributed in Canada and five other countries. It's a 1:1 CBD-THC whole plant extract. "It's a very good medicine," Dr. Frankel says. "But it's expensive. That's the problem with pharmaceutical [companies]." Dr. Frankel also consults with various states that are interested in growing medicinal CBD, i.e. cannabis with a high CBD content and hemp-level (extremely low) THC. He even gives the CBD seeds away. "I make the offer: if any governor in the 50 states wants, absolutely free – as long as I can do it legally – any of these high-ratio CBD strains, I can make it happen. No cost," he says.

"This is one of the important points I'd to emphasize: I think we're going to find ultimately that CBD is a nutritional supplement for everybody. I think we were all using [cannabis] 100 years ago... I think then, if they had hemp for food, there was CBD in it. Again, I wasn't there, but my guess is that everybody had CBD in their diet up until 100 years ago or so. CBD appears in some of the newest data to help protect your DNA epigenetic layer. That's important stuff for all of the toxins that we have in our environment. I think we have more toxins now, and we're missing one of the major protectants that we used to use for this. That's a double whammy."

Source: http://articles.mercola.com/sites/articles...

Medical Studies show Cannabis cures Cancer

I recently was emailed the latest article on 420 Insight's website. I wanted to pass it along because it specifically deals with Cannabis and Cancer. The article was written by Arjun Walia and what I like about it is that it lists all the links to the studies for the different cancers.

This is an important article because one of the difficult obstacles someone with cancer deals with are FAMILY MEMBERS. Family members who will probably disagree with the way one goes about treatment, especially if it is non mainstream! With this information below one can give this information to the family members that are having a fit so that they are better educated about cannabis and how it affects cancer cells. Read and decide for yourselves! Thank you to 420 insight for the great articles and videos!  Elizabeth Knight

By Arjun Walia

The health benefits of Cannabis are vast, with multiple medical and scientific studies that confirm them. On the other hand, arguments against the use of marijuana is usually published in Psychiatric journals, which show no scientific evidence that Cannabis is harmful to human health. All psychological evaluations from the intake of cannabis are largely based on assumptions, suggestions and observations (1). When we look at the actual science behind Cannabis, the health benefits can be overwhelming. So what does one who opposes the use of cannabis base their belief on? Nothing, not scientific evidence anyways. The negative stigmatism attached to marijuana is due to it’s supposed psychotropic effects, yet again, there is no scientific evidence to show that marijuana has any psychotropic effects. Nonetheless, cannabis has recently been the focus of medical research and considered as a potential therapeutic treatment and cure for cancer.

Cannabis is a great example of how the human mind is programmed and conditioned to believe something. Growing up, we are told drugs are bad, which is very true, however not all substances that have been labelled as “drugs” by the government are harmful. Multiple substances are labelled as a “drug” in order to protect corporate interests. One example is the automobile and energy industry, a car made from hemp is stronger than steel, and can be fueled from hemp alone. Henry Ford demonstrated this many years ago. Hemp actually has over 50,000 uses!

Let’s take a look at the science behind Cannabis and Cancer. Although Cannabis has been proven to be effective for a large range of ailments, this article will focus mainly on it’s effectiveness in the treatment of cancer. Cannabinoids may very well be one of the best disease and cancer fighting treatments out there. Cannabinoids refer to any of a group of related compounds that include cannabinol and the active constituents of cannabis. They activate cannabinoid receptors in the body. The body itself produces compounds called endocannabinoids and they play a role in many processes within the body that help to create a healthy environment. Cannabinoids also play a role in immune system generation and re-generation. The body regenerates best when it’s saturated with Phyto-Cannabinoids. Cannabinoids can also be found in Cannabis. It is important to note that the cannabinoids are plentiful in both hemp and cannabis. One of the main differentiations between hemp and cannabis is simply that hemp only contains 0.3% THC while cannabis is 0.4% THC or higher. (Technically they are both strains of Cannabis Sativa.) Cannabinoids have been proven to reduce cancer cells as they have a great impact on the rebuilding of the immune system. While not every strain of cannabis has the same effect, more and more patients are seeing success in cancer reduction in a short period of time by using cannabis.

While taking a look at these studies, keep in mind that cannabis can be much more effective for medicinal purposes when we eat it rather than smoking it. Below are 20 medical studies that prove cannabis can be an effective treatment and possible cure for cancer. Please keep in mind that this is a very short list of studies that support the use of medicinal marijuana. Please feel free to further your research, hopefully this is a good starting point.

Brain Cancer

1 – A study published in the British Journal of Cancer, conducted by the Department of Biochemistry and Molecular Biology at Complutense University in Madrid, this study determined that Tetrahydrocannabinol (THC) and other cannabinoids inhibit tumour growth. They were responsible for the first clinical study aimed at assessing cannabinoid antitumoral action. Cannabinoid delivery was safe and was achieved with zero psychoactive effects. THC was found to decrease tumour cells in two out of the nine patients.

2 – A study published in The Journal of Neuroscience examined the biochemical events in both acute neuronal damage and in slowly progressive, neurodegenerative diseases. They conducted a magnetic resonance imaging study that looked at THC (the main active compound in marijuana) and found that it reduced neuronal injury in rats. The results of this study provide evidence that the cannabinoid system can serve to protect the brain against neurodegeneration.

3 – A study published in The Journal of Pharmacology And Experimental Therapeutics already acknowledged the fact that cannabinoids have been shown to possess antitumor properties. This study examined the effect of cannabidiol (CBD, non psychoactive cannabinoid compound) on human glioma cell lines. The addition of cannabidiol led to a dramatic drop in the viability of glioma cells. Glioma is the word used to describe brain tumour. The study concluded that cannabidiol was able to produce a significant antitumor activity.

4 – A study published in the journal Molecular Cancer Therapeutics outlines how brain tumours are highly resistant to current anticancer treatments, which makes it crucial to find new therapeutic strategies aimed at improving the poor prognosis of patients suffering from this disease. This study also demonstrated the reversal of tumour activity in Glioblastoma multiforme.

Breast Cancer

5 – A study published in the US National Library of Medicine, conducted by the California Pacific Medical Centre determined that cannabidiol (CBD) inhibits human breast cancer cell proliferation and invasion. They also demonstrated that CBD significantly reduces tumour mass.

6 – A study published in The Journal of Pharmacology and Experimental Therapeutics determined that THC as well as cannabidiol dramatically reduced breast cancer cell growth. They confirmed the potency and effectiveness of these compounds.

7 – A study published in the Journal Molecular Cancer showed that THC reduced tumour growth and tumour numbers. They determined that cannabinoids inhibit cancer cell proliferation, induce cancer cell apoptosis and impair tumour angiogenesis (all good things). This study provides strong evidence for the use of cannabinoid based therapies for the management of breast cancer.

8 – A study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) determined that cannabinoids inhibit human breast cancer cell proliferation.

Lung Cancer

9 – A study published in the journal Oncogene, by Harvard Medical Schools Experimental Medicine Department determined that THC inhibits epithelial growth factor induced lung cancer cell migration and more. They go on to state that THC should be explored as novel therapeutic molecules in controlling the growth and metastasis of certain lung cancers.

10 – A study published by the US National Library of Medicine by the Institute of Toxicology and Pharmacology, from the Department of General Surgery in Germany determined that cannabinoids inhibit cancer cell invasion. Effects were confirmed in primary tumour cells from a lung cancer patient. Overall, data indicated that cannabinoids decrease cancer cell invasiveness.

11 – A study published by the US National Library of Medicine, conducted by Harvard Medical School investigated the role of cannabinoid receptors in lung cancer cells. They determined its effectiveness and suggested that it should be used for treatment against lung cancer cells.

Prostate Cancer

12 – A study published in the US National Library of Medicine illustrates a decrease in prostatic cancer cells by acting through cannabinoid receptors.

13 – A study published in the US National Library of Medicine outlined multiple studies proving the effectiveness of cannabis on prostate cancer.

14. Another study published by the US National Library of Medicine determined that clinical testing of CBD against prostate carcinoma is a must. That cannabinoid receptor activation induces prostate carcinoma cell apoptosis. They determined that cannabidiol significantly inhibited cell viability.

Blood Cancer

15 – A study published in the journal Molecular Pharmacology recently showed that cannabinoids induce growth inhibition and apoptosis in matle cell lymphoma. The study was supported by grants from the Swedish Cancer Society, The Swedish Research Council and the Cancer Society in Stockholm.

16 – A study published in the International Journal of Cancer also determined and illustrated that cannabinoids exert antiproliferative and proapoptotic effects in various types of cancer and in mantle cell lymphoma.

17 – A study published in the US National Library of Medicine conducted by the Department of Pharmacology and Toxicology by Virginia Commonwealth University determined that cannabinoids induce apoptosis in leukemia cells.

Oral Cancer

18 – A study published by the US National Library of Medicine results show cannabinoids are potent inhibitors of cellular respiration and are toxic to highly malignant oral Tumours.

Liver Cancer

19 – A study published by the US National Library of Medicine determined that that THC reduces the viability of human HCC cell lines (Human hepatocellular liver carcinoma cell line) and reduced the growth.

Pancreatic Cancer

20 – A study published in The American Journal of Cancer determined that cannabinoid receptors are expressed in human pancreatic tumor cell lines and tumour biopsies at much higher levels than in normal pancreatic tissue. Results showed that cannabinoid administration induced apoptosis. They also reduced the growth of tumour cells, and inhibited the spreading of pancreatic tumour cells.

Sources: 

All sources highlighted throughout article. Click on the highlighted parts of the article to view them.

1)http://bjp.rcpsych.org/content/178/2/116.full

Cannabis OIL Cancer Cure: Dr. Raphael Mechoulam discusses medical cannabis. From marijuana nation.

Source: http://420insight.com/research/medical-stu...

Fighting Holiday Anxiety with Cannabinoids

So this is the time of year that people all over travel to spend time with their families, but it can also be a very stressful time for many. There are many people that struggle with the anxiety of expectations and also depression. It's hard to feel "UP" when you don't have a family and feel very alone. 

This is when some turn to self medication whether it be prescription drugs or alcohol to help them cope. Did you know that a High CBD tincture can help? Cannabidiol has gone through many studies and trials with very promising results, here is a list from Project CBD's website that lists a number of PubMed studies and their results....yes, it's sometimes hard to read through all the abstract scientific language, but usually at the end there is a summary which is helpful!

Anxiety

So, if you suffer from life's stresses, social anxiety, panic attacks and also depression which for many is mulitplied this time of year, please check this information out and share it with the people you love!

Thank you Project CBD for the wonderful information you provide to the public to educate and give hope.

Cheers,

Elizabeth

Pianta Tinta

Share this:

Source: http://www.projectcbd.org/conditions/anxie...

5 Differences between THC and CBD

The following is an article from 420 Insight. For people not familiar with the different components of cannabis or think cannabis is all about the "high" please read on. The comment I have is about sleep. We have many members that use CBD for sleep. From the feedback we get, lower doses of CBD can help with sleep issues while higher doses can boost energy it's all about paying attention to how it works in YOUR BODY!!

Cannabidiol (CBD) and tetrahydrocannabinol (THC) are the two main ingredients in the marijuana pelant. Both CBD and THC belong to a unique class of compounds known as cannabinoids.

While many strains of marijuana are known for having abundant levels of THC, high-CBD strains are less common. But CBD has recently started to draw attention from the medical community, who seem to prefer CBD over THC. Here, we explain the differences between these two compounds.

1) THE HIGH

THC is probably best known for being the psychoactive ingredient in marijuana. CBD, however, is non-psychoactive. In other words, CBD can’t get you high. While disappointing to recreational users, this unique feature of CBD is what makes it so appealing as a medicine.

Doctors usually prefer treatments with minimal side effects, which has been a major barrier to the acceptance of medical marijuana. Likewise, CBD has been used to treat younger children with various ailments.
 

2) ANXIETY


THC is known to cause some people to feel anxious or paranoid. But CBD is believed to have the opposite effect. In fact, studies show that CBD works to counteract the anxiety caused by ingesting THC. A number of studies also suggest that CBD can reduce anxiety when administered on its own.
 

3) ANTIPSYCHOTIC


In addition to being non-psychoactive, CBD seems to have antipsychotic properties. Researchers believe that CBD may protect marijuana users from getting too high by reducing the psychosis-like effects of THC. However, regulating the mind-altering activity of THC isn’t all that CBD is good for. On its own, CBD is being tested as an antipsychotic medicine for people with schizophrenia.
 

4) SLEEP


One of the most common uses of marijuana is as a sleep aid. THC is believed to be responsible for most of marijuana’s sleep-inducing effects. On the other hand, studies suggest CBD acts to promote wakefulness, making CBD a poor choice as a sleep medicine. The opposite effects of CBD and THC on sleep may explain why some strains of cannabis cause users to feel drowsy while others are known to boost energy.
 

5) LEGAL STATUS


While most countries have strict laws surrounding marijuana and THC, the legal status of CBD is less clear. In the United States, CBD is technically illegalsince it is classified as a Schedule I drug under federal law. A pharmaceutical form of CBD, called Epidiolex, was only recently cleared by the FDA to be tested in children with severe epilepsy.

On the other hand, CBD is found in hemp, which can be legally imported and sold in the U.S. Some companies have taken advantage of this loophole by importing high-CBD hemp extracts from other countries where hemp is produced.

Study: Cannabis May Treat Aggressive Forms Of Breast Cancer

Breast Cancer.... I have had a number of people in my life that have been through it, some survived, some did not. There are more and more studies being done on cannabis for the treatment of many cancers, both using THC and CBD. All one needs to do is go to www.pubmed.com and type in cannabis & cancer, or CBD & cancer and up pops many studies that have been done. Both THC and CBD have anti-tumor effects. 

Drake Dorm who is a writer for Medical Jane, wrote the following article on October 17, 2014

Medical Marijuana May Benefit Breast Cancer Patients

Contrary to popular belief, breast cancer is not one disease – it is an umbrella term used for many different diseases, according to HER2 Support Group. HER2-positive breast cancer is a particularly aggressive type that forms when there is an over-expression of the HER2 gene. 

Not only does HER2-positive breast cancer grow rapidly, but it is often associated with a poor prognosis and high recurrence rates. Although successful treatments have been designed to target the HER2 gene in particular, research reports that they do not garner a response from everyone.

As we know, cannabis has shown promise in treating a wide variety of cancers, and a Japanese study found cannabinoids to inhibit tumor growth. Accordingly, breast cancer research has turned to medical marijuana for answers.

Spanish Researchers Treated Breast Cancer With Cannabinoids

In 2010, a team of Spanish researchers published a study in the journal Molecular Cancer with the intent to “determine whether cannabinoids might constitute a new therapeutic tool” in the treatment of HER2-positive breast cancer. They analyzed the anti-tumor potential of tetrahydrocannabinol (THC)and a synthetic cannabinoid with similar effects to cannabidiol (CBD).

In order to analyze each cannabinoid’s potential, the researchers investigated their effects on mice with a similar form of cancer – the Mouse Mammary Tumor Virus. In addition to mouse trials, the researchers examined the effects of cannabis on 87 human breast tumors.

“Cannabinoids may inhibit [cancerous] cell proliferation and induce programmed cell death.”

According to the study’s results, THC and CBD had a number of anti-cancer benefits in mice. Both cannabinoids investigated were found to inhibit cancer growth, reduce the number of tumors, and reduce the number and/or severity of metastases (secondary tumors in the lungs).

In studying the human cancer tissue, the researchers found that cannabinoids may inhibit cell proliferation and induce programmed cell death, or aptosis. According to the study, cannabinoids also seem to “impair tumor angiogenesis,” which allows tumors to receive more nutrients by causing blood vessels to grow.

One of the most pertinent findings, according to the study, is that 91% of HER2-positive tumors actively express CB2 receptors. As we know, both THC and CBD interact with CB2 receptors, and this could explain their interaction with breast cancer.

More research will be necessary before determining whether medical marijuana is an effective form of breast cancer treatment, but the results of the Spanish study are intriguing. Cannabis is currently used to counter nausea and other side effects of chemotherapy, but evidence of its anti-cancer potential is growing. If scientifically proven to treat HER2-positive breast cancer, medical marijuana may replace chemotherapy as a follow-up to surgery.

Source: http://www.medicaljane.com/2013/10/17/stud...

Get Your SUPER HIGH!!

We are proud to present our newest products, SUPER High CBD Tincture and our 50/50 blend!!

These are available for purchase to our members....not a member? It's free to sign up! You must have a doctor's recommendation and CDL...please visit our website for more information....

Here's a sneak peak

SUPER High CBD Tincture:

20 mg/ml CBD (600mg CBD per 1oz!!)

0.72 mg/ml THC

Non-Psychoactive

Lab Tested - Steep Hill Halent

1 fl. oz/ 30ml

$99.00

 

 

50/50 BLEND 

12 MG/ML CBD

9.3MG/ML THC

LAB TESTED - STEEP HILL HALENT

1 FL.OZ/30ML

$60

 

 

 

All test results are listed on our website...feel free to call or email us!

Not all CBD tinctures are the same!!

Tinctures offer the best way to deliver nutrients in stable soluble form, optimal for assimilation. Tinctures retain volatile and semi volatile ingredients, usually lost in heat treated and especially reprocessed dry extracts. The importance of these ingredients for health beneficial action is hard to overestimate.

Due to convenient dosing, tinctures are one of the safest herbal preparations on the market

One of the things that people overlook when buying a High CBD tincture or oil is what is on the label! Make sure that the CBD content is listed so that you know how much of it you are getting and if you are paying a fair price. In liquid the CBD is measured in mg per ml. There is approximately 30 ml of liquid in a 1 fl oz bottle. If the label says for instance that there is 3 mg per ml of CBD, then there is a total of 90mg of CBD in that 1 oz bottle.  Some companies charge a high price for a very low amount of CBD content so it is important to shop around. With a higher quality tincture with a higher CBD content per bottle (250-300 mg) would mean you can take less of the product and get great results. 

Another number to look at is the ratio between the CBD and THC. Our tincture has a 22:1 ratio meaning there is 22 times more CBD than THC!

  1. Consider the condition you’re treating. For anxietydepressionspasms, and pediatric seizure disorders, you may do better with a moderate dose of a CBD-dominant remedy—look for a CBD:THC ratio of more than 14:1. For cancer or pain, you may need more THC, for instance, a 1:1 ratio.

So, just because a product says High CBD on the label, or Ultra High CBD, don't assume that's what it is.... Do a little research on your own and make sure they list the test results either on their label or on their website!!  It's a bit like our food industry, some labels say the product is all natural yet it is filled with junk!!

European Study: What Is The Best Cannabis Oil Extraction Method?

“Ethanol and olive oil were determined to be the most effective, largely because of their ability to produce an extract with a high terpene content. Perhaps more importantly, both substances are safe for consumption.”

This is an article from February 2014 by Drake Dram, writer for Medical Jane. There is alot of controversy in the different extraction methods and what is safe. We use the ethanol extraction method and we have many beneficial terpenes left in our High CBD tinctures,

Please read on....Elizabeth

Cannabis extract medicine has been used for generations to help treat a variety of conditions, and its popularity has increased quite a bit in recent years. Much of this increased popularity can be traced to Rick Simpson‘s public campaign in favor of what he referred to as “hemp oil.”

Last year, a group of researchers from the University of Siena (Italy) and Leiden University (Netherlands) completed a study last year with some of the most commonly used extraction solvents to see how they stack up. Their results were published in the journal Cannabinoids.

Cannabis Extraction Solvents Discussed By Caregivers, Researchers

As previously reported, Rick advocated for the use of naphtha or petroleum ether – a fact for which he has taken criticism. The argument being made is not that these substances are ineffective as solvents, but that it creates an unnecessary danger for patients.

As noted by, Dr. Luigi L. Romano, lead author of the European study, naphtha and petroleum ether are mixtures of various hydrocarbons (benzene, hexane, etc.). He goes on to explain, “they are each considered cancer hazards according to their respective Material Safety Data Sheets (MSDS) provided by manufacturers.”

There are a number of alternative extraction methods that have gained popularity in recent years – some intended for inhalation (butane, CO2, propane, etc), and others geared toward oral ingestion (ethanol, olive oil, coconut oil, etc.). It should come as no surprise that each substance reacts differently when used as a solvent, and the final product can be greatly affected by the process used to extract the highly coveted cannabis oil.

Researchers Test Efficacy Of Various Cannabis Extract Solvents

With this in mind, the European research team investigated the effectiveness of four extraction solvents – naphtha, petroleum ether, ethanol and olive oil. They performed a total of five extractions, including two slightly different methods of olive oil extraction. Lab test results from each final product were then analyzed for their respective cannabinoid and terpene content.

“Ethanol and olive oil were determined to be the most effective, largely because of their ability to produce an extract with a high terpene content. Perhaps more importantly, both substances are safe for consumption.”

Of the solvents used, naphtha showed the most significant difference. Naphtha-based cannabis oil displayed a lower concentration of terpenes and a much higher percentage of decarboxylated tetrahydrocannabinol (THC) compared to the other extracts.

On the other hand, ethanol and olive oil were determined to be the most effective, largely because of their ability to produce an extract with a high terpene content. Perhaps more importantly, both substances are safe for consumption.

Many developments are being made in the realm of cannabis oil and a movement is underway to end the use of harmful solvents like naphtha in the case of medical marijuana patients. In fact, a Colorado-based concentrate company named OG recently released a line of capsules filled with solventless RSO and patients have reported broad spectrum benefits.

Source: http://www.medicaljane.com/2014/02/20/euro...

What is this AC/DC?

Since this is the strain that is used in our High-CBD tinctures, here is a short article on the AC/DC strain and why it is so special!

The AC/DC Strain Is A Phenotype of Cannatonic

As we know, cannabidiol (CBD) has come to the forefront in recent years, and a number of cultivators have set out to develop CBD-rich strains, like Sour Tsunami and Ghost Rider, and Harlequin. Bred by Resin Seeds, the Cannatonic strain certainly helped pave the way for this trend, becoming one of the first strains recorded with a 1:1 ratio of CBD:THC.

“AC/DC is a phenotype of the Cannatonic strain with a documented 22:1 CBD:THC ratio.”

With that said, just 50 percent of Cannatonic seeds will develop into CBD-rich plants. Understandably, this can cause confusion for medical cannabis patients.

The strain’s cannabinoid profile tends to vary greatly – I’ve seen test results of Cannatonic with CBD:THC ratios ranging everywhere from 20:1 to 1:20.

With this in mind, a phenotype of the Cannatonic strain with a 22:1 CBD:THC ratio has adopted the nickname “AC/DC.” It has been made available in the form of clones and is currently making it’s way throughout California. In fact, a number of northern California’s premier dispensary locations have reported an availability of AC/DC clones, including Harborside Health Center (Oakland) and Synergy Wellness (Santa Rosa).

How Will The AC/DC Cannabis Strain Affect Me?

Being a CBD-rich strain, the AC/DC phenotype of the Cannatonic strain is often sought out for its ability to deliver relief without psychoactive side effects. Because of this, it is unlikely to garner much interest from the adult-use market.

“It’s high concentration of cannabidiol (CBD) makes the AC/DC strain ideal for coping with anxiety and pain.”

Nonetheless, a number of medical marijuana patients seek out clones of the AC/DC strain to add to their garden. It’s high concentration of cannabidiol (CBD) makes the AC/DC strain ideal for anxiety and pain.

Furthermore, cannabis oil from the AC/DC phenotype and juicing its leaves have each shown promise in preventing the spread of cancer according to anecdotal reports. Consider this strain if suffering from epilepsymultiple sclerosis, or the negative effects of chemotherapy.

This article was written by Drake Dram, a writer for the online site, Medical Jane. 

Source: http://www.medicaljane.com/review/acdc-str...

So now I have the medicine...now what?

So now that you have your medicine...now what?  Many people do not know where to start when it comes to dosing. It is a very individual thing, everyone is different as to how they react to medicines so this is guideline only! It would be a very wise idea to keep a daily journal of where you start, how many drops per dose you take, how many times per day you take that dose, etc...  More is not always better!

Please read the last paragraph of this blog as it is very important!!

Elizabeth, Pianta Tinta

www.piantacbd.com

 

 

Dosing Guidelines

A patient’s sensitivity to THC is a key factor in determining

Appropriate dosages for a CBD-rich treatment regimen.

 

CBD (Cannabidiol)                                                    THC (tetrahydrocannabinol)

Non-psychoactive                                                      Psychoactive – may produce Euphoric or                                                                                                    dysphoic effects

                                                                                                      

 Cannabis therapeutics is personalized medicine. The appropriate dosage depends upon the person and condition being treated.

 Accept 100% responsibility for your problem and credit for the cure:  You are responsible for your quality of health and happiness. You are responsible for finding a successful treatment. You are responsible determining the correct do

 

Chose the medium for the medicine:

Tinctures, excellent

Raw solid cannabis, poor

Juiced raw cannabis, poor

Oils, excellent

Concentrates, good but risky

 

Choose a pathway:

Lungs: avoid

Digestive: good, but takes time

Sub-lingual: excellent

Rectal or Vaginal: excellent

Topical: good

         

Begin with a low dose: especially if you have little or no experience with                cannabis.

 

Take a few small doses over the course of the day rather than one big dose.

 

Use the same dose and ratio for several days. Observe the effects and consider if you need to adjust the ratio or amount.

 

Don’t overdo it: Often with cannabinoid therapeutics, “less is more.” Cannabinoid

compounds have biphasic properties. This means that higher doses of CBD can sometimes be less effective than low or moderate ones. Also, too much THC—while not lethal—can increase anxiety and mood disorders.

 

The universal approximate dose of cannabinoids for mammals: 5 to 10 milligrams per 100 pounds of Human body weight.

                                                     

Potency levels:

Potency or milligrams of cannabinoids may not be on the package labels

Initially follow the recommended dosage on the package

Experiment with small doses in 5-hour intervals

Increase doses gradually until the optimal approximate dose is achieved

Maintain dosage level when the effective level is reached

 

Change dosage as the conditions of the disease changes:

Management of dosage will change as the indicators change. Stay sensitive to the effectiveness of dosages.

Cannabinoids are stored in our system therefore reducing the dose is usually the best tactic for successful treatment.

Avoid increasing dose due to the inverse effects generated by excess cannabinoids in the system. Research has shown that when our cannabinoid receptors are full over time, the body decreases the receptors made so it is advised to take a 48 hour break from the medicine to clear it out of your system. This should be done once a month.